Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. [PDF]
, 2009 During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages.
Häcker Georg +20 more
core +2 more sources
Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia [PDF]
, 2002 Heterozygous mutations in neutrophil elastase have been detected in many sporadic cases of congenital neutropenia. However, a convincing pathogenetic mechanism has not been established, and it is unclear whether the effects of the mutant enzyme occur ...
Ancliff, PJ +13 more
core +1 more source
Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]
, 2009 Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga +15 more
core +1 more source
Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]
, 1990 Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Schiffl, H. +3 more
core +1 more source
Effect of Lonomia obliqua Venom on Human Neutrophils
Toxins, 2021 The significant incidence of deforestation in South America culminates in the contact of humans with typical forests species. Among these species, one may highlight Lonomia obliqua caterpillar, which, when touched by humans, can poison them through their
João Alfredo Moraes +8 more
doaj +1 more source
Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia
Cells, 2022 Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single functional assays. Cell functions are interwoven pathways, and understanding
Kylie B. R. Belchamber +13 more
doaj +1 more source
Redox BiologyAcute lung injury (ALI) is a respiratory insufficiency syndrome precipitated by factors such as infection, sepsis, or systemic trauma. Excessive polymorphonuclear neutrophil (PMN) infiltration and activation represent the hallmark cellular features of ...
Hangfei Jin +6 more
doaj +1 more source
Neutrophil Activated by the Famous and Potent PMA (Phorbol Myristate Acetate)
Cells, 2022 This review will briefly outline the major signaling pathways in PMA-activated neutrophils. PMA is widely used to understand neutrophil pathways and formation of NETs.
Hylane Luiz Damascena +3 more
doaj +1 more source
ResearchThe diversity of neutrophils’ subtypes and functions in the tumor microenvironmentunderlies their contributions to both pro- and anti-tumorigenic activities.
Yunxi Yang +7 more
doaj +1 more source
Three-dimensional migration of neutrophils through an electrospun nanofibrous membrane
BioTechniques, 2015 The study of immune cell migration is important for understanding the immune system network, which is associated with the response to foreign cells. Neutrophils act against foreign cells before any other immune cell, and they must be able to change shape
Songwan Jin +7 more
doaj +1 more source