Results 41 to 50 of about 688,534 (290)

Reliable genetic diagnosis of NCF1 (p47phox)-deficient chronic granulomatous disease using high-throughput sequencing

Frontiers in Immunology
IntroductionChronic granulomatous disease is caused by mutations in any of the 6 components of the phagocytic NADPH oxidase complex including gp91phox, p47phox, p22phox, p40phox, p67phox, or EROS.
Amy P. Hsu, Eric Karlins, Justin Lack, Justin Lack, T. Joseph Pepper, Karen Lau, Kimberly R. Marshall-Batty, Debra Long Priel, Joie Davis, Danielle L. Fink, Christa S. Zerbe, John I. Gallin, Harry L. Malech, Steven M. Holland, Douglas B. Kuhns   +14 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Cell Transplantation
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies.
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun   +6 more
doaj   +1 more source

Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients [PDF]

, 2015
Aim: To investigate the chemotactic accuracy of peripheral blood neutrophils from patients with chronic periodontitis compared with matched healthy controls, before and after non-surgical periodontal therapy.
Agarwal, Andrew, Bagorda, Berridge, Biemond, Bostan, Brock, Cedergren, Champagne, Chapple, Chapple, Chapple, Choi, Clark, Cooper, Cotter, Daniel, Dias, Dias, Dias, Dickinson, Dietrich, Dyke, Dyke, Dyke, Dyke, Dyke, Fu, Fujita, Gamonal, Graves, Grossi, Haastert, Harvath, Henry, Herlihy, Herlihy, Kantarci, Kaul, Kolaczkowska, Kuiper, Kumar, Kurihara, Lakshman, Lambeth, Lavine, Matthews, Matthews, Miesel, Mizuno, Muinonen-Martin, Nibali, Niethammer, Nishizuka, Offenbacher, Pablo, Page, Partida-Sanchez, Phillips, Rahman, Sackmann, Samanta, Sapey, Toker, Tsai, Tyagi, Van Dyke, Wells, Worthen, Wright, Yagi, Yoshikawa, Zigmond   +72 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Neutrophil-Camouflaged Stealth Liposomes for Photothermal-Induced Tumor Immunotherapy Through Intratumoral Bacterial Activation

Pharmaceutics
Objective: F. nucleatum, a tumor-resident bacterium colonizing breast cancer (BC), results in an immunosuppressive microenvironment and facilitates tumor growth and metastasis.
Xinxin Chen, Jiang Sun, Tingxian Ye, Fanzhu Li   +3 more
doaj   +1 more source

The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils

Frontiers in Immunology, 2021
Human neutrophils express two unique antibody receptors for IgG, the FcγRIIa and the FcγRIIIb. FcγRIIa contains an immunoreceptor tyrosine-based activation motif (ITAM) sequence within its cytoplasmic tail, which is important for initiating signaling. In
Omar Rafael Alemán, Nancy Mora, Carlos Rosales   +2 more
doaj   +1 more source

The effects of honey compared with sucrose and a sugar-free diet on neutrophil phagocytosis and lymphocyte numbers after long-term feeding in rats [PDF]

, 2007
To determine whether honey and sucrose would have differential effects on levels of neutrophil phagocytosis after long-term feeding 36 2-month old Sprague Dawley rats were fed a powdered diet that was either sugar-free or contained 7.9% sucrose or 10 ...
Chepulis, Lynne Merran
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source