Results 11 to 20 of about 447,015 (215)

Pocket ACEs: Discovering new function within an old player

Frontiers in Physiology, 2023
Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and ...
Matthew Leong, Xiaomo Li, Manita Chaum
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Effect of Lonomia obliqua Venom on Human Neutrophils

Toxins, 2021
The significant incidence of deforestation in South America culminates in the contact of humans with typical forests species. Among these species, one may highlight Lonomia obliqua caterpillar, which, when touched by humans, can poison them through their
João Alfredo Moraes, Genilson Rodrigues, Daniel Guimarães-Bastos, Vany Nascimento-Silva, Erik Svensjö, Mariana Renovato-Martins, Markus Berger, Jorge Guimarães, Christina Barja-Fidalgo   +8 more
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Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia

Cells, 2022
Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single functional assays. Cell functions are interwoven pathways, and understanding
Kylie B. R. Belchamber, Onn S. Thein, Jon Hazeldine, Frances S. Grudzinska, Aduragbemi A. Faniyi, Michael J. Hughes, Alice E. Jasper, Kay Por Yip, Louise E. Crowley, Sebastian T. Lugg, Elizabeth Sapey, Dhruv Parekh, David R. Thickett, Aaron Scott   +13 more
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Mechanical stress promotes excessive NETs and exacerbates acute lung injury via Piezo1-mediated mitochondrial dysfunction

Redox Biology
Acute lung injury (ALI) is a respiratory insufficiency syndrome precipitated by factors such as infection, sepsis, or systemic trauma. Excessive polymorphonuclear neutrophil (PMN) infiltration and activation represent the hallmark cellular features of ...
Hangfei Jin, Yiwen Mei, Xi Gao, Wenwen Zhang, Heyue Li, Yitian Chen, Bingwei Sun   +6 more
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Neutrophil Activated by the Famous and Potent PMA (Phorbol Myristate Acetate)

Cells, 2022
This review will briefly outline the major signaling pathways in PMA-activated neutrophils. PMA is widely used to understand neutrophil pathways and formation of NETs.
Hylane Luiz Damascena, Wendy Ann Assis Silveira, Mariana S. Castro, Wagner Fontes   +3 more
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Highly Selective Exogenous Neutrophils Effectively Inhibit Growth of Colon Cancer under the Guidance of Precision Navigation

Research
The diversity of neutrophils’ subtypes and functions in the tumor microenvironmentunderlies their contributions to both pro- and anti-tumorigenic activities.
Yunxi Yang, Chuyu Li, Yiming Shao, Xiao Wen, Cheng Lu, Xi Gao, Yiwen Mei, Bingwei Sun   +7 more
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Three-dimensional migration of neutrophils through an electrospun nanofibrous membrane

BioTechniques, 2015
The study of immune cell migration is important for understanding the immune system network, which is associated with the response to foreign cells. Neutrophils act against foreign cells before any other immune cell, and they must be able to change shape
Songwan Jin, Tae-Min Park, Cho-Hee Kim, Jin-Soo Kim, Binh Duong Le, Young Hun Jeong, Jong-Young Kwak, Sik Yoon   +7 more
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A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model

Biomolecules, 2022
Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H2O2 to form several degradation products, some of which have been detected in vivo and may contribute to the ...
Fei-Fei Yu, Yao Yuan, Yan Ao, Li Hua, Wu Wang, Yiyi Cao, Jing Xi, Yang Luan, Shangwei Hou, Xin-Yu Zhang   +9 more
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Dynamic CD177/CD10 ratio for infection diagnosis and mortality risk stratification in critically ill patients: a prospective cohort studyResearch in context

EBioMedicine
Summary: Background: Two crucial needs persist in delivering effective critical care: reliable differentiation of infectious vs non-infectious systemic inflammation and detection of impending sepsis before the occurrence of organ dysfunction.
Jiamin Huang, Keliang Xie, Heyue Li, Xiao Wen, Yiwen Mei, Jiahui Chen, Aixiang Yang, Bingwei Sun   +7 more
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Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Cell Transplantation
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies.
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun   +6 more
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