Results 121 to 130 of about 152,807 (272)

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation

Pulmonary Medicine, 2016
Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors.
Ilana Cruz-Silva, Viviane Abreu Nunes, Andrezza Justino Gozzo, Priscila Praxedes-Garcia, Aparecida Sadae Tanaka, Kazuaki Shimamoto, Mariana Silva Araujo   +6 more
doaj   +1 more source

Preparation and Characterization of a Monoclonal Antibody That Inhibits Human Neutrophil Elastase Activity

, 1988
Neutrophil proteases are believed to play a role in the pathogenesis of a variety of human diseases. While many studies of proteases in models of disease have focused on elastase, neutrophils contain several proteases some of which share a high degree of
Beulah H Gray, Keith M Skubitz, Nancy G Wehner   +2 more
core   +1 more source

Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis

, 2020
Introduction: Neutrophilic inflammation is a major driver of bronchiectasis pathophysiology, and neutrophil elastase activity is the most promising biomarker evaluated in sputum to date.
Gramegna, Andrea, Chalmers, James D., Sulaiman, Imran, Chalmers, James D, Ruggiero, Luca, Saderi, Laura, Sotgiu, Giovanni, Segal, Leopoldo N, Wu, Benjamin, Marchisio, Paola, Blasi, Francesco, Oriano, Martina, Segal, Leopoldo N., Aliberti, Stefano, Terranova, Leonardo   +14 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

, 2015
© ERS 2015. Neutrophil elastase is the most significant predictor of bronchiectasis in early-life cystic fibrosis; however, the causal link between neutrophil elastase and airway damage is not well understood.
Kevin Looi (23288020), S. Ranganathan (21825869), K.M. Ling (23500672), E. Kicic-Starcevich (23453170), L.W. Garratt (23500696), Thomas Iosifidis (23288107), K.M. Martinovich (23500846), D.A. Knight (23500711), S.M. Stick (23500693), Anthony Kicic (23288017), N.C. Shaw (23500894), E.N. Sutanto (23500705)   +11 more
core   +2 more sources

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis

The Journal of Clinical Investigation
Neutrophil infiltration occurs in a variety of liver diseases, but it is unclear how neutrophils and hepatocytes interact. Neutrophils generally use granule proteases to digest phagocytosed bacteria and foreign substances or neutralize them in neutrophil
Noriyoshi Ogino, M. Fatima Leite, Mateus T. Guerra, Emma Kruglov, Hiromitsu Asashima, David A. Hafler, Takeshi Ito, João P. Pereira, Brandon J. Peiffer, Zhaoli Sun, Barbara E. Ehrlich, Michael H. Nathanson   +11 more
doaj   +1 more source

Neutrophil-mediated epithelial injury during transmigration: role of elastase

, 2001
Neutrophil-mediated injury to gut epithelium may lead to disruption of the epithelial barrier function with consequent organ dysfunction, but the mechanisms of this are incompletely characterized.
Vera Cherapanov, Qin Dong, Hedy H. Ginzberg, Andre Cantin, Christopher A. G. McCulloch, Patrick T. Shannon, Gregory P. Downey   +6 more
core   +1 more source