Results 161 to 170 of about 152,807 (272)

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Differential Regulation of Neutrophil Elastase Release vs. NET Generation After Cardiopulmonary Bypass. [PDF]

Int J Mol Sci
Murray ET, Hook JS, Patel P, Xie L, Moreland J.   +4 more
europepmc   +1 more source

Inhaled Heparin to Shorten Antibiotic Duration in Ventilator‐Associated Pneumonia: A Randomized Double‐Blind Controlled Trial

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Prolonged antibiotic therapy in ventilator‐associated pneumonia (VAP) contributes to antimicrobial resistance. Inhaled heparin has pleiotropic anti‐inflammatory and mucolytic properties. This trial evaluated whether adjunctive nebulized heparin reduces antibiotic duration in VAP using a procalcitonin (PCT)‐guided ...
Anoush Dehnadi Moghadam, Mostafa Saeedinia, Fatemeh Dehnadi Moghadam   +2 more
wiley   +1 more source

A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier. [PDF]

Signal Transduct Target Ther
Stojkovic B, Bekkers M, Violi JP, Neilan BA, Ying TH, Keely S, Donald WA, Riveros C, Kaiko GE.   +8 more
europepmc   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source

Human Neutrophil Elastase and the Protein-Storm Axis: Reversible Synthetic Inhibitors in Inflammatory Disease. [PDF]

Molecules
Viglio S, Grignano MA, Gregorini M, Rampino T, Pietrocola G, Iadarola P.   +5 more
europepmc   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Plasma levels of inhibitor-bound leukocytic elastase in rheumatoid arthritis patients [PDF]

, 1984
Mallaya, R. K., Heidland, A., Schnebli, H. P., Hörl, W. H., Christen, P., Jochum, Marianne, Pepys, M. B.   +6 more
core   +1 more source

Development of atropisomeric 5<i>N</i>-sulfonyl-1,5-benzodiazepin-2-ones with high inhibitory activity against neutrophil elastase. [PDF]

RSC Med Chem
Tabata H, Miyata Y, Kusakabe Y, Takahashi H, Natsugari H, Oshitari T.   +5 more
europepmc   +1 more source

Dynamic Changes of Neutrophil Nuclear Membrane CD63 as a Potential Biomarker for Early Adjunctive Diagnosis and Prognostic Evaluation of Sepsis in Critically Ill Patients: A Prospective Cohort Study

MedComm, Volume 7, Issue 10, October 2026.
Here, we report that nuclear membrane CD63 (nmCD63), a marker of targeted nuclear degranulation in neutrophils, represents a novel biomarker for sepsis. In a two‐center prospective cohort with independent external validation, nmCD63 outperforms CRP and PCT for early sepsis diagnosis, with the nmCD63+SOFA combined model reaching an AUC of 0.943.
Xingxin Gao, Min Zhang, Linbin Li, Haihua Lyu, Zhihao Liu, Xucheng Wei, Dehui Li, Yiming Shao   +7 more
wiley   +1 more source