Results 111 to 120 of about 847,167 (258)

Neutrophil-Targeted Polyphenol-Based Nanoassembly Modulates Nets/Glycolysis For Periodontitis

International Dental Journal
Aim or purpose: Inhibition of neutrophil extracellular trap formation and HK-2-regulated macrophage gated glycolysis for periodontitis treatment Materials and methods: Neutrophil-targeted nanoparticles were synthesized via polyphenol(EGCG)-amino acid(5 ...
Kai Zhang, Xinyi Tang
doaj   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

BackgroundC-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Peter, K, Hildebrand, Frank, Markus Huber-Lang, Eisenhardt, Steffen Ulrich, Berger, Bettina, Uwe Knippschild, Klemens Horst, Bläsius, Felix M., Braig, David, Lena Schütte, David Alexander Christian Messerer, Knippschild, Uwe, Anke Schultze, Karasu, Ebru, Frank Hildebrand, Horst, Klemens, Steffen U. Eisenhardt, Berger, B, Schultze, A, Greven, J, Messerer, David Alexander Christian, Bettina Berger, Braig, D, Schütte, L, Horst, K, Rebecca Halbgebauer, Johannes Zeller, Johannes Greven, Huber-Lang, M, Huber-Lang, Markus, Feuerstein, H, Zeller, Johannes, Peter, Karlheinz, Felix M. Bläsius, Halbgebauer, R, Winninger, Oscar, Hendrik Feuerstein, Knippschild, U, Schütte, Lena M., Hildebrand, F, Zeller, J, Karlheinz Peter, Ebru Karasu, Schultze, Anke, David Braig, Messerer, DAC, Feuerstein, Hendrik, Oscar Winninger, Karasu, E, Greven, Johannes, Bläsius, FM, Halbgebauer, Rebecca, Winninger, O, Eisenhardt, SU   +53 more
core   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Neutrophil Extracellular Trap is Surrogate Biomarker for Prognosis and Response to Neoadjuvant Therapy in Locally Advanced Rectal Cancer

, 2023
Wentao Zhong,1– 3,* Qianyu Wang,2,* Xiaofei Shen,4,* Yuan Lv,2,3 Liang Sun,2 Ran An,5 Hongyan Zhu,5 Huiyun Cai,2 Gang Chen,2,3 Aijun Liu,5 Junfeng Du1– 3 1The Second School of Clinical Medicine, Southern Medical University, Guangdong, 510515,
Sun L, An R, Wang Q, Lv Y, Chen G, Zhong W, Liu A, Zhu H, Du J, Shen X, Cai H   +10 more
core  

Neutrophil Extracellular Traps Are Associated With Early Neurological Deterioration in Patients With Acute Ischemic Stroke Receiving Intravenous Thrombolysis: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Neutrophil extracellular traps contribute to thrombolytic resistance and the no‐reflow phenomenon after acute ischemic stroke, thereby impairing microvascular reperfusion and leading to unfavorable clinical outcomes.
Lulu Pei, Wan Zhang, Ding Zhang, Zhaoyang Zhao, Yifang Zhou, Ce Zong, Jiaxin Wang, Zixin Chen, Hanbing Zhao, Yiwei Qian, Mengke Tian, Xinjing Liu, Hui Fang, Wenzheng Rong, Kai Liu, Yapeng Li, Xiaohan Xu, Xinyi Leng, Ming‐ming Ning, Duolao Wang, Yuming Xu, Bo Song   +21 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

Calcium-dependent redox signaling connects mitochondrial remodeling with PAD-associated NETosis during respiratory mycoplasma infection

Redox Biology
Neutrophil extracellular trap (NET) formation is controlled by redox signaling and mitochondrial stress, but the connection between pathogen-induced Ca2+ influx, mitochondrial remodeling, and PAD-associated chromatin execution remains insufficiently ...
Shun Wang, Weiqi Liu, Fuhua Gu, Jian Wang, Yuquan Guo, Liyang Guo, Yifan Li, Kexin Wang, Jie Zhang, Yecheng Yao, Zhiyong Wu, Jichang Li   +11 more
doaj   +1 more source