Results 101 to 110 of about 847,167 (258)

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation [PDF]

, 2019
Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial ...
Jim Wu, Hanna Bonnekoh, Sheila Hoffmann, Marcus Maurer, Karoline Krause, Jörg Scheffel   +5 more
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Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

, 2010
Neutrophil interaction with activated endothelial cells (EC) is required for transmigration. We examined consequences of this interaction on NETosis. Co-culture of activated EC with neutrophils induced neutrophil extracellular trap (NET) formation, which
Paul Erne, Maria Philippova, Therese J. Resink, Gupta, Anurag Kumar, Philippova, Maria, Hasler, Paul, Paul Hasler, Anurag Kumar Gupta, Sinuhe Hahn, Joshi, Manjunath B., Erne, Paul, Hahn, Sinuhe, Resink, Therese J., Manjunath B. Joshi, Hasler P, Gupta AK, Philippova M, Resink TJ, Erne P, Hahn S, Joshi MB   +20 more
core   +1 more source

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

Nature Communications, 2017
DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK ...
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan, David M. Markovitz   +19 more
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Pathogenic Bacterium Acinetobacter baumannii Inhibits the Formation of Neutrophil Extracellular Traps by Suppressing Neutrophil Adhesion

Frontiers in Immunology, 2018
Hospital-acquired infections caused by Acinetobacter baumannii have become problematic because of high rates of drug resistance. A. baumannii is usually harmless, but it may cause infectious diseases in an immunocompromised host. Although neutrophils are
Go Kamoshida, Takane Kikuchi-Ueda, Satoshi Nishida, Shigeru Tansho-Nagakawa, Tsuneyuki Ubagai, Yasuo Ono   +5 more
doaj   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

A NETs-centric multi-omics framework prioritizes PGLYRP1 and MMP9 as subtype-associated thromboinflammatory biomarker candidates and putative therapeutic hypotheses in ischemic stroke

Neurobiology of Disease
Neutrophil extracellular traps are implicated in immunothrombosis and neuroinflammation in ischemic stroke, but blood-based markers that distinguish subtype-specific thromboinflammatory patterns remain limited.
Haozhou Tan, Haoyu Gong, Hui Li, Mengyao Huang, Jingyuan Zhang, Yan Liu, Ying Li, Yuanjian Song, Qian Feng   +8 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Neutrophil extracellular trap-formation following Blastomyces dermatitidis yeast stimulation

, 2016
Blastomycosis, a potentially fatal infection results from an infection developing from a thermo-dimorphic fungal pathogen Blastomyces dermatitidis. The pivotal points driving the pathogenesis associated with the varied clinical presentations are not ...
Ratekin, A.K.
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