Results 81 to 90 of about 847,167 (258)

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al.
Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight   +12 more
doaj   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Activation of Neutrophil Extracellular Trap Formation in Patients with Heart Failure and a Preserved Ejection Fraction [PDF]

Introduction: Pathophysiological differences between heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) remain poorly understood.
LANG, CHIM C.; id_orcid, MICHAELSEN, NATASHA B.M., TROMP, JASPER, CONDE-KNAPE, KARIN, THARSHANA, GANASH N., VOORS, ADRIAAN A., NATH, MINTU, DJORDJEVIC, DJORDJE, VAN ESSEN, BART J., BAUMHOVE, LUKAS, BAUMHOVE, LUKAS; id_orcid, KOEKEMOER, ANDREA, OUWERKERK, WOUTER, De Jong, TRISTAN V., SAMANI, NILESH J., GEVAERT, ANDREAS B., LANG, CHIM C., VAN ESSEN, BART J.; id_orcid, Michaelsen, Natasha B. M., Tharshana, Ganesh N., Voors, Adriaan A, Lang, Chim C   +21 more
core   +1 more source

Platelet-Neutrophil Interplay: Insights Into Neutrophil Extracellular Trap (NET)-Driven Coagulation in Infection

Frontiers in Cardiovascular Medicine, 2019
Well established for their central role in hemostasis, platelets have increasingly been appreciated as immune cells in recent years. This emerging role should not come as a surprise as the central immune cells of invertebrates, hemocytes, are able to ...
Amanda Z. Zucoloto, Craig N. Jenne
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Neutrophil extracellular traps as the main source of eDNA

, 2017
Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed DNA together with accompanying proteins, including histones and antimicrobial peptides released from activated neutrophils as part of the first-line defence against ...
Marzena Wątek, Ewelina Piktel, Grzegorz Król, Robert Bucki, Bonita Durnaś, Mateusz Cieśluk, Tomasz Wollny   +6 more
core   +1 more source

Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity [PDF]

, 2017
There are over 6 billion vaccine doses administered each year, most containing aluminium-based adjuvants, yet we still do not have a complete understanding of their mechanisms of action.
D. Erben, Benson, R.A., Erben, D, Stephen, J., H. E. Scales, Erben, D., P. Garside, Brewer, J.M., Stephen, J, J. Stephen, Scales, H.E., Garside, P, Scales, H E, Garside, P., J. M. Brewer, R. A. Benson, Benson, R A, Brewer, J M   +17 more
core   +1 more source

Identification of potential biological processes and key genes in diabetes-related stroke through weighted gene co-expression network analysis

BMC Medical Genomics
Background Type 2 diabetes mellitus (T2DM) is an established risk factor for acute ischemic stroke (AIS). Although there are reports on the correlation of diabetes and stroke, data on its pathogenesis is limited.
Yong He, Yang Bai, Qin Huang, Jian Xia, Jie Feng   +4 more
doaj   +1 more source

NLRP3 inflammasome activation is associated with type 1 inflammation and neutrophil activation in pyoderma gangrenosum across human and murine models

JID Innovations
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful, nonhealing cutaneous ulcers. Although dysregulated innate immunity and neutrophil activation are implicated in its pathogenesis, the underlying molecular mechanisms ...
Takeshi Araki, Akihiko Uchiyama, Rimu Takata, Keiji Kosaka, Mayu Ohtaka, Shintaro Saito, Takayuki Shuto, Akiko Sekiguchi, Sachiko Ogino, Yoko Yokoyama, Ryoko Torii, Yuki Watanuki, Sei-ichiro Motegi   +12 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source