Results 91 to 100 of about 689,523 (253)

Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps

Frontiers in Immunology, 2019
Pseudomonas aeruginosa is the most prevalent opportunistic pathogen in the airways of cystic fibrosis (CF) patients. The pulmonary disorder is characterized by recurrent microbial infections and an exaggerated host inflammatory immune response led ...
Sladjana Skopelja-Gardner, Jomkuan Theprungsirikul, Kimberley A. Lewis, John H. Hammond, Kyrsten M. Carlson, Haley F. Hazlett, Amanda Nymon, Dao Nguyen, Brent L. Berwin, Deborah A. Hogan, William F. C. Rigby, William F. C. Rigby   +11 more
doaj   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Neutrophil extracellular traps in tissue pathology [PDF]

, 2017
Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs
Nakazawa, Daigo, Desai, Jyaysi, Anders, Hans Joachim, Kumar, Santhosh V.   +3 more
core   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Neutrophil extracellular traps characterize caseating granulomas

Cell Death and Disease
Tuberculosis (TB) remains one of the top 10 causes of death worldwide and still poses a serious challenge to public health. Recent attention to neutrophils has uncovered unexplored areas demanding further investigation.
Leticija Zlatar, Jasmin Knopf, Jeeshan Singh, Han Wang, Marco Muñoz-Becerra, Irmgard Herrmann, Rebecca C. Chukwuanukwu, Markus Eckstein, Philip Eichhorn, Ralf J. Rieker, Elisabeth Naschberger, Andreas Burkovski, Veit Krenn, Rostyslav Bilyy, Tetiana Butova, Iryna Liskina, Ihor Kalabukha, Oleg Khmel, Michael Boettcher, Georg Schett, Dmytro Butov, Anton Tkachenko, Martin Herrmann   +22 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier [PDF]

Jingjing Yu,1,2,* Ziang Meng,1,2,* Xuxu Liu,1,2 Yi Zheng,1,2 Dongbo Xue,1,2 Chenjun Hao,1,2 Liyi Wang1,2 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’ s Republic ...
Liu X, Zheng Y, Xue D, Yu J, Meng Z, Hao C, Wang L   +6 more
core  

Identification of a Novel 4-gene Prognostic Model Related to Neutrophil Extracellular Traps for Colorectal Cancer

Background/Aims: Colorectal cancer (CRC) is a significant global health concern, and understanding the molecular mechanisms underlying CRC progression and prognosis is crucial. Neutrophil extracellular traps (NETs) have been implicated in various cancers,
Dong Cao, Jiyun Duan, Junwen Qian
core   +1 more source

New insights on the inhibition of neutrophil extracellular traps enzymes in equine endometrium

, 2021
Tese de Doutoramento em Ciências Veterinárias na especialidade de Ciências Biológicas e BiomédicasMares physiologically develop a post-breeding endometritis characterized by a fast arrival of neutrophils into the uterine lumen.
Amaral, Ana Sofia Pires
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source