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Automated flow cytometric quantification of human neutrophil extracellular traps (NETs)
Rinaldi G +10 more
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Neutrophil extracellular traps in cancer
Seminars in Cancer Biology, 2022Beyond their well-known functions in the acute phases of the immune response, neutrophils play important roles in the various phases of tumor initiation and progression, through the release of their stored or newly synthesized mediators. In addition to reactive oxygen species, cytokines, chemokines, granule proteins and lipid mediators, neutrophil ...
Leonardo Cristinziano +6 more
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Rethinking neutrophil extracellular traps
International Immunopharmacology, 2023Neutrophils are a major subset of leukocytes in human circulating blood. In some circumstances, neutrophils release neutrophil extracellular traps (NETs). lnitially, NETs were considered to have a strong antibacterial capacity. However, currently, NETs have been shown to have a pivotal impact on various diseases.
Yi Liu +10 more
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Neutrophil extracellular traps: neutrophil’s afterlife
Hirurg (Surgeon), 2021This paper is a literature review on the origin, structure and functioning of neutrophil extracellular traps (NETs) that are released from neutrophils through NETosis, the kind of cell death. NETs are comprised of DNA, histones and neutrophil granule enzymes.
Olga Yaroslavna Porembskaya +7 more
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Extracellular neutrophil traps in periodontitis
Journal of Periodontal Research, 2009Background and Objective: Chronic periodontitis, the chronic inflammatory disease of the periodontium, is caused by bacteria and is characterized by an influx of neutrophils into the gingival crevice. Recently, a ‘new’ extracellular neutrophil defense mechanism – neutrophil extracellular traps – has been described. However, their role in periodontitis
L, Vitkov +3 more
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Neutrophil Extracellular Traps in Sepsis
Shock, 2014Sepsis is the leading cause of death in critically ill patients in intensive care units. Early recognition of sepsis and proper therapy are essential to reduce patient mortality. Moreover, treatment options for this deleterious inflammatory response to infection are limited.
Camicia, Gabriela Lorena +2 more
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Neutrophil Extracellular Traps Kill Bacteria
Science, 2004Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill
Brinkmann, V. +7 more
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Neutrophil extracellular traps and neutrophilic asthma
Respiratory MedicineThere are more than 260 million asthma patients worldwide. How to provide targeted long-term standardized treatment and management still confuses clinical workers and patients. Neutrophilic asthma is a special type of asthma which is difficult to diagnose clinically and often associated with severe asthma and glucocorticoid resistance.
Jiayi, Xiang, Muyan, Cui, Yuling, Zhang
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Neutrophil Extracellular Trap in Human Diseases
2012NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill ...
Araźna, Magdalena +3 more
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