Results 51 to 60 of about 75,140 (320)

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

medRxiv, 2020
Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19).
P. Skendros, Alexandros Mitsios, A. Chrysanthopoulou, D. Mastellos, S. Metallidis, P. Rafailidis, Maria Ntinopoulou, Eleni N. Sertaridou, V. Tsironidou, C. Tsigalou, Maria Tektonidou, Theocharis G Konstantinidis, C. Papagoras, I. Mitroulis, Georgios Germanidis, John D Lambris, K. Ritis   +16 more
semanticscholar   +1 more source

Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth

Cell Communication and Signaling, 2023
Background Inflammation-related predisposition to cancer plays an essential role in cancer progression and is associated with poor prognosis. A hypoxic microenvironment and neutrophil infiltration are commonly present in solid tumours, including gastric ...
Jiachen Li, Yu Xia, Biying Sun, Nanbei Zheng, Yang Li, Xuehan Pang, Fan Yang, Xingwang Zhao, Z. Ji, Haitao Yu, Fu-jun Chen, Xuemei Zhang, Bin Zhao, Jiaqi Jin, Shifeng Yang, Zhuoxin Cheng   +15 more
semanticscholar   +1 more source

Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]

, 2014
Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad, Carlson, Adam Q, Graf, Jonathan, Imboden, John B, Jen, Kuang-Yu, Sam, Ramin, Tuot, Delphine S   +6 more
core   +2 more sources

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Frontiers in Immunology, 2023
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate.
Mengting Yao, Jiacheng Ma, Dongwen Wu, Chucun Fang, Zilong Wang, Tianting Guo, J. Mo   +6 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps: New Aspects [PDF]

Moscow University Biological Sciences Bulletin, 2020
Neutrophils are the "first line" of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky characterized one more neutrophil effector function-the release of neutrophil extracellular traps (or NETs).
openaire   +2 more sources

Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]

, 2015
Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall, AK Neumann, B Amulic, B Enjalbert, B Hube, BN Gantner, C Jiménez-López, C Sasse, C Tokarski, CC Sheth, CF Urban, CGJ McKenzie, CJ Chrisman, D Armstrong-James, D Ermert, D Liebl, D Vijayan, DA Silva da, DC Savage, DJ Krysan, E Moreno-Ruiz, EK Szabo, FM Rudkin, G Chamilos, G Vande Velde, GD Brown, GD Brown, H Ma, H Ma, I Rubin-Bejerano, IE Frohner, J Behnsen, J Chandra, J Maertens, J Perlroth, J Voigt, JM Bain, JM Tam, Judith Bain, K Konig, K Schäfer, K Seider, KM Brothers, L Romani, L Romani, Lars-Peter Erwig, LE Lewis, LE Lewis, LG Tilney, LY Ngo, M Alvarez, MC Lorenz, MG Netea, MJ Patterson, MS Lionakis, MS Lionakis, N Papon, NAR Gow, Neil A. R. Gow, O Uzun, O Zaragoza, P Martino, P Miramón, Q Qian, R García-Rodas, RA Drummond, RD Diamond, RI Lehrer, S Bruns, S El-Kirat-Chatel, S Keppler-Ross, S Mitra, SA Johnston, SC Cheng, SE Heinsbroek, V Aimanianda, Wellington, Y Luo   +77 more
core   +1 more source

Neutrophil extracellular traps promote angiogenesis in gastric cancer

Cell Communication and Signaling, 2023
Although antiangiogenic therapy has been used in gastric cancer, disease progression due to drug resistance remains common. Neutrophils play an important role in the occurrence and progression of cancer via neutrophil extracellular traps (NETs). However,
Shifeng Yang, Boshi Sun, Jiachen Li, Nan Li, Ange Zhang, Xinyu Zhang, Hao Yang, Xiaoming Zou   +7 more
semanticscholar   +1 more source

Neutrophil Extracellular Traps [PDF]

, 2019
Neutrophil extracellular traps (NETs) are made of a network of extracellular strings of DNA that bind pathogenic microbes. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. Reactive oxygen species generated by the neutrophil NADPH oxidase have been shown to be essential to mediate NET ...
openaire   +2 more sources

Neutrophil Extracellular Traps (NETs) and Vasculitis [PDF]

International Journal of Medical Sciences, 2021
Background: Neutrophil extracellular traps (NETs) have been implicated in host immune responses. Attempts have been made to examine how NETs affect the pathogenesis of complications such as autoimmune and vascular disorders. Aim: This study aimed to explore the relationship between NETs and vasculitis.
Arneth, Borros, Arneth, Rebekka, Justus Liebig University Giessen   +2 more
openaire   +3 more sources

Neutrophil extracellular traps (NETs) : formation and implications [PDF]

, 2013
Neutrophils are cells of the immune system which freely circulate in blood vessels and are recruited to the inflammation sites when the human organism responds to microbial infections.
Rąpała-Kozik, Maria, Zawrotniak, Marcin   +1 more
core   +1 more source