Results 31 to 40 of about 32,634 (246)

Evolution of neutrophil extracellular traps in the pathology of stroke

Neural Regeneration Research
Stroke is a major cause of death and disability worldwide, and its pathogenesis is complex, involving multiple pathological processes, such as thrombosis, ischemia-reperfusion injury, inflammatory response, and blood–brain barrier disruption.
Wenjing Ning, Qian Wang, Yuzhen Xu
doaj   +1 more source

Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction and Resolution of Sterile Crystal-Mediated Inflammation

Frontiers in Immunology, 2018
The formation of neutrophil extracellular traps (NETs) to immobilize pathogens represents a novel antimicrobial strategy of the immune system. The microcrystals related to human diseases are classified into endogenous microcrystals, including monosodium ...
Yanhong Li, Xue Cao, Yi Liu, Yi Zhao, Yi Zhao, Martin Herrmann   +5 more
doaj   +1 more source

Neutrophil extracellular traps in sheep mastitis [PDF]

Veterinary Research, 2015
Neutrophil extracellular traps (NETs) are structures composed of DNA, histones, and antimicrobial proteins that are released extracellularly by neutrophils and other immune cells as a means for trapping and killing invading pathogens. Here, we describe NET formation in milk and in mammary alveoli of mastitic sheep, and provide a dataset of proteins ...
Pisanu S., Cubeddu T., Pagnozzi D., Rocca S., Cacciotto C., Alberti A., Marogna G., Uzzau S., Addis M. F.   +8 more
openaire   +3 more sources

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source

Stroke-derived neutrophils demonstrate higher formation potential and impaired resolution of CD66b + driven neutrophil extracellular traps

BMC Neurology, 2022
Background Recent evidence suggests a merging role of immunothrombosis in the formation of arterial thrombosis. Our study aims to investigate its relevance in stroke patients. Methods We compared the peripheral immunological profile of stroke patients vs.
Angeliki Datsi, Laura Piotrowski, Markella Markou, Thomas Köster, Isabelle Kohtz, Kerstin Lang, Sabine Plöttner, Heiko Udo Käfferlein, Burkhard Pleger, Ramon Martinez, Bogdan Pintea, Roland Fried, Marcus Müller, Rene Chapot, Konstantinos Gousias   +14 more
doaj   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis [PDF]

, 2020
AbstractDespite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (
Thomas M, Hofbauer, Anna S, Ondracek, Irene M, Lang   +2 more
openaire   +2 more sources

Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus

Современная ревматология, 2021
Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease.
K. S. Nurbaeva, T. M. Reshetnyak, A. M. Lila   +2 more
doaj   +1 more source

Inhibitors of Polyphosphate and Neutrophil Extracellular Traps

Seminars in Thrombosis and Hemostasis, 2023
AbstractThe contact pathway of blood clotting has received intense interest in recent years as studies have linked it to thrombosis, inflammation, and innate immunity. Because the contact pathway plays little to no role in normal hemostasis, it has emerged as a potential target for safer thromboprotection, relative to currently approved antithrombotic ...
Vappala, Sreeparna, Smith, Stephanie A., Kizhakkedathu, Jayachandran N., Morrissey, James H.   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Neutrophil extracellular traps in cancer progression [PDF]

Cellular and Molecular Life Sciences, 2014
Neutrophils are being increasingly recognized as an important element in tumor progression. They have been shown to exert important effects at nearly every stage of tumor progression with a number of studies demonstrating that their presence is critical to tumor development.
Cools-Lartigue, Jonathan, Spicer, Jonathan, Najmeh, Sara, Ferri, Lorenzo   +3 more
openaire   +2 more sources