Results 21 to 30 of about 689,523 (253)

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Haematologica, 2013
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel, Erfan Nur, Bart J. Biemond, Gerard J. van Mierlo, Shabnam Solati, Dees P. Brandjes, Hans-Martin Otten, John-John Schnog, Sacha Zeerleder   +8 more
doaj   +1 more source

Neutrophil Extracellular Traps, Angiogenesis and Cancer

Biomedicines, 2022
Human neutrophils, the most abundant circulating leukocytes, are fundamental components of the host response against different pathogens. Until a few years ago, neutrophils received limited attention in cancer immunology. Recently, it was discovered that
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi   +7 more
doaj   +1 more source

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

Haematologica, 2017
Neutrophils, early mediators of the innate immune defense, are recruited to developing thrombi in different types of thrombosis. They amplify intravascular coagulation by stimulating the tissue factor-dependent extrinsic pathway via inactivation of ...
Susanne Pfeiler, Konstantin Stark, Steffen Massberg, Bernd Engelmann   +3 more
doaj   +1 more source

Neutrophil extracellular traps go viral

Frontiers in Immunology, 2016
Neutrophils are the most numerous immune cells. Their importance as a first line of defense against bacterial and fungal pathogens is well described. In contrast, the role of neutrophils in controlling viral infections is less clear. Bacterial and fungal
Günther Schönrich, Martin J Raftery
doaj   +1 more source

Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia

BMC Cardiovascular Disorders, 2020
Background This study investigated neutrophil activation and neutrophil-derived extracellular traps formation in coronary artery ectasia. Methods We enrolled 90 patients who underwent coronary angiography, and included 30 patients with coronary artery ...
Yuchao Guo, Ruifeng Liu, Lianfeng Chen, Wei Wu, Shuyang Zhang   +4 more
doaj   +1 more source

Neutrophil extracellular traps [PDF]

, 2013
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-
Wagner, Denisa, Demers, Mélanie
core   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis [PDF]

, 2017
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin.
Doering, Yvonne, Soehnlein, O, Weber, Christian, Soehnlein, Oliver, Weber, C, Döring, Yvonne, Yvonne Döring, Oliver Soehnlein, Döring, Y, Christian Weber   +9 more
core   +1 more source

Evolution of neutrophil extracellular traps in the pathology of stroke

Neural Regeneration Research
Stroke is a major cause of death and disability worldwide, and its pathogenesis is complex, involving multiple pathological processes, such as thrombosis, ischemia-reperfusion injury, inflammatory response, and blood–brain barrier disruption.
Wenjing Ning, Qian Wang, Yuzhen Xu
doaj   +1 more source

Neutrophil extracellular traps as the main source of eDNA

, 2017
Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed DNA together with accompanying proteins, including histones and antimicrobial peptides released from activated neutrophils as part of the first-line defence against ...
Marzena Wątek, Ewelina Piktel, Grzegorz Król, Robert Bucki, Bonita Durnaś, Mateusz Cieśluk, Tomasz Wollny   +6 more
core   +1 more source

Neutrophil antimicrobial defense against Staphylococcus aureus. contribution of cathelicidin and the NADPH oxidase [PDF]

, 2009
Neutrophils are among the most important components of the innate immune response, which provides the first line of host defense. The antimicrobial potential of neutrophils has been traditionally divided into either non-oxidative or oxidative ...
Jann, Naja
core   +1 more source