Results 21 to 30 of about 32,634 (246)
Neutrophil extracellular traps [PDF]
Current Biology, 2011 What are neutrophil extracellular traps, or NETs? Neutrophils, the most abundant immune cells in humans, are the first line of defense against invading pathogens. They employ a wide array of anti-microbial strategies, most notably phagocytosis, to attack and eliminate pathogens.
Amulic, Borko, Hayes, Garret
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Surgery Open Science, 2020 Background: Colorectal cancer is the third most common cancer worldwide. Almost half of those that have a potentially curative resection go on to develop metastatic disease.
Georgia M. Carroll, BMed, PGDip +7 more
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Neutrophil extracellular traps — the dark side of neutrophils [PDF]
Journal of Clinical Investigation, 2016 Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by
Sørensen, Ole E., Borregaard, Niels
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Neutrophil Extracellular Traps [PDF]
, 2013 Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than
Viviana Marin-Esteban +2 more
+6 more sources
Neutrophil Extracellular Traps in Host Defense [PDF]
Cold Spring Harbor Perspectives in Biology, 2019 Neutrophils are produced in the bone marrow and then patrol blood vessels from which they can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill invading microbes via a suite of defense mechanisms. Diverse extracellular and intracellular microbes induce neutrophils to extrude neutrophil extracellular traps (NETs)
Sabrina Sofia Burgener, Kate Schroder
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Nucleosomes and neutrophil activation in sickle cell disease painful crisis
Haematologica, 2013 Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel +8 more
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Propagation of thrombosis by neutrophils and extracellular nucleosome networks
Haematologica, 2017 Neutrophils, early mediators of the innate immune defense, are recruited to developing thrombi in different types of thrombosis. They amplify intravascular coagulation by stimulating the tissue factor-dependent extrinsic pathway via inactivation of ...
Susanne Pfeiler +3 more
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BMC Cardiovascular Disorders, 2020 Background This study investigated neutrophil activation and neutrophil-derived extracellular traps formation in coronary artery ectasia. Methods We enrolled 90 patients who underwent coronary angiography, and included 30 patients with coronary artery ...
Yuchao Guo +4 more
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Diagnostics, 2022 Neutrophil granulocytes are a central component of the innate immune system. In recent years, they have gained considerable attention due to newly discovered biological effector functions and their involvement in various pathological conditions.
Heiko Pfister
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Neutrophil Extracellular Traps [PDF]
, 2019 Neutrophil extracellular traps (NETs) are made of a network of extracellular strings of DNA that bind pathogenic microbes. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. Reactive oxygen species generated by the neutrophil NADPH oxidase have been shown to be essential to mediate NET ...
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