Results 121 to 130 of about 845,167 (291)

Assessment of antineutrophil extracellular traps antibodies (ANETA) in the serum of systemic lupus erythematosus patients and its relation to disease activity and damage

Journal of the Egyptian Women’s Dermatologic Society
Background Neutrophil extracellular trap formation (NETosis) is a distinct mechanism of neutrophil cell death and has been increasingly implicated in the pathogenesis of systemic lupus erythematosus (SLE) and other autoimmune disorders.
Rofaida El Naggar, Sarah A.A. Nasser, Amal H. Eissa, Tamer A. Gheita, Noha A.R. Nagui   +4 more
doaj   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps

Frontiers in Immunology, 2018
Neutrophil extracellular traps (NETs) consist of a decondensed DNA scaffold decorated with neutrophil-derived proteins. The proteome of NETs, or “NETome,” has been largely elucidated in vitro.
Chun Hwee Lim, Chun Hwee Lim, Sunil S. Adav, Sunil S. Adav, Siu Kwan Sze, Yeu Khai Choong, Rathi Saravanan, Artur Schmidtchen, Artur Schmidtchen   +8 more
doaj   +1 more source

Root extracellular traps versus neutrophil extracellular traps in host defence, a case of functional convergence?

, 2019
International audienceThe root cap releases cells that produce massive amounts of mucilage containing polysaccharides, proteoglycans, extracellular DNA (exDNA) and a variety of antimicrobial compounds. The released cells – known as border cells or border‐
Boulogne, Isabelle, Sophie Bernard, Smith, Catherine, Maïté Vicré, Carine Smith, John Moore, Chambard, Marie, Vicré, Maïté, Marc Ropitaux, Moore, John P., Ropitaux, Marc, Driouich, Azeddine, Bernard, Sophie, Isabelle Boulogne, Marie‐Laure Follet‐Gueye, Marie Chambard, Azeddine Driouich   +16 more
core   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome

, 2014
A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies.
Blom, Anna,, Leffler, Jonatan,, Bogdanovic, Gordana, Hesselstrand, Roger,, Stojanovich, Ljudmila, Lund University., Shoenfeld, Yehuda   +6 more
core   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Neutrophil extracellular traps (NETs): Relevance to thrombosis and hemostasis. A narrative review

Romanian Journal of Laboratory Medicine
Neutrophil extracellular traps (NETs) are released by neutrophils and comprise web-like structures that play a vital role in fighting infections. NETs have also been involved in various thrombosis and hemostasis mechanisms.
Alamin Amin A.
doaj   +1 more source

Epigenetic Activation of ANGPTL4 Drives EBV‐Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5

Advanced Science, EarlyView.
ANGPTL4 exhibits distinct promoter methylation patterns and expression profiles in EBV‐positive versus EBV‐negative gastric cancer. Secreted C‐terminal ANGPTL4 (cANGPTL4) acts as the dominant functional isoform driving GC proliferation, EMT, and neutrophil infiltration. cANGPTL4 promotes neutrophil recruitment via NF‐κB/CXCL8 axis.
Dandan Li, Xinqi Li, Xiangyin Luo, Jiayi Wang, Yiwei Zha, Zeng Zhou, Yanyan Chen, Qi Wang, Lingyun Xia, Weidong Leng, Shanshan Qin   +10 more
wiley   +1 more source