Results 101 to 110 of about 845,167 (291)

Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection

Journal of Arthropod-Borne Diseases
Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to ...
Cucunawangsih Cucunawangsih, Ratna Sari Wijaya, Nata Pratama Hardjo Lugito, Ivet Suriapranata   +3 more
doaj   +1 more source

Neutrophil Extracellular Traps and Neutrophil-Derived Extracellular Vesicles: Common Players in Neutrophil Effector Functions

, 2022
Neutrophil granulocytes are a central component of the innate immune system. In recent years, they have gained considerable attention due to newly discovered biological effector functions and their involvement in various pathological conditions.
Pfister, Heiko, Heiko Pfister
core   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

Neutrophil Extracellular Traps (NETs) in cancer and beyond

South East European Journal of Immunology
Neutrophils play a major role in tumor biology. The main effects described by us and others of neutrophils in cancer are directly on tumor cells, or indirectly by affecting the stromal immune system. An exciting relatively novel phenomenon described is the neutrophils' ability to release webs of fibrous decondensed chromatin named neutrophil ...
Nuha Al-Sharif, Mohamad Qaisi, Naomi Kaisar, Dan Padawer, Osnath Bohana, Yael Volman, Zvi G. Fridlender   +6 more
openaire   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release

JHEP Reports
Background & Aims: The role of infiltrating neutrophils in hepatocellular carcinoma (HCC) is modulated by cellular metabolism, specifically lipid homeostasis.
Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang   +9 more
doaj   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps.

, 2021
Neutrophil extracellular traps (NETs) are structures consisting of chromatin and antimicrobial molecules that are released by neutrophils during a form of regulated cell death called NETosis.
Andreeva, L., Hopfner, K., Streeck, R., Apel, F., Zychlinsky, A., Knackstedt, L., Goosmann, C., Frese, C., Robert Streeck, Arturo Zychlinsky, Falko Apel, Liudmila Andreeva, Karl-Peter Hopfner, Christian Karl Frese, Lorenz Sebastian Knackstedt, Christian Goosmann   +15 more
core   +1 more source

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis [PDF]

Journal of Thrombosis and Haemostasis, 2008
A C, Ma, P, Kubes
openaire   +2 more sources

The effect of clindamycin and amoxicillin on neutrophil extracellular trap (NET) release

Central European Journal of Immunology, 2016
Neutrophil extracellular traps (NETs) are threads of nuclear DNA complexed with antimicrobial proteins released by neutrophils to extracellular matrix to bind, immobilise, and kill different pathogens. NET formation is triggered by different physiological and non-physiological stimulants. It is also suggested that antibiotics could be non-physiological
Weronika Kuźmicka, Moskalik, Aneta, Sieczkowska, Sandra, Aneta Manda-Handzlik, Urszula Anna Demkow, Olga Ciepiela   +5 more
openaire   +2 more sources