Results 1 to 10 of about 1,212 (168)

Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

Acta Pharmaceutica Sinica B
Tumor relapse and metastasis are the major causes of mortality associated with urothelial cancer. In the tumor microenvironment, negative regulatory molecules and various immune cell subtypes suppress antitumor immunity. The inflammatory microenvironment,
Zezhong Mou, Lujia Zou, Xinan Chen
exaly   +3 more sources

Neutrophil Extracellular Trap-Driven Occlusive Diseases

Cells, 2021
The enlightenment of the formation of neutrophil extracellular traps (NETs) as a part of the innate immune system shed new insights into the pathologies of various diseases. The initial idea that NETs are a pivotal defense structure was gradually amended
Kursat Oguz Yaykasli, Christine Schauer, Luis E. Muñoz, Aparna Mahajan, Jasmin Knopf, Georg Schett, Martin Herrmann   +6 more
doaj   +1 more source

NETome: A model to Decode the Human Genome and Proteome of Neutrophil Extracellular Traps

Scientific Data, 2022
Measurement(s) Genome Sequence Reads • Protein Abundance Technology Type(s) Illuminia • liquid chromatography-tandem mass spectrometry Factor Type(s) Neutrophil extracellular trap genome sequence • Neutrophil extracellular trap protein abundance Sample ...
David Scieszka, Yi-Han Lin, Weizhong Li, Saibyasachi Choudhury, Yanbao Yu, Marcelo Freire   +5 more
doaj   +1 more source

Impaired neutrophil extracellular trap formation in β-thalassaemia/HbE

Scientific Reports, 2022
Neutrophil dysfunction contributes to a high susceptibility to severe bacterial infection which is a leading cause of morbidity and mortality in β-thalassaemia/HbE, especially in splenectomised patients.
Rattanawan Thubthed, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo   +7 more
doaj   +1 more source

Composite Hydrogel Modulates Intrinsic Immune-Cascade Neovascularization for Ocular Surface Reconstruction after Corneal Chemical Injury

Gels, 2023
Ocular alkali burns recruit neutrophils and triggers neutrophil extracellular trap (NET)-neovascularization cascade effects that limit ocular surface reconstruction and functional repair.
Jun Zhang, Kun Xi, Guohua Deng, Xi Zou, Peirong Lu   +4 more
doaj   +1 more source

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

Mediators of Inflammation, 2020
Ischemia reperfusion (IR) can lead to acute kidney injury and can be complicated by acute lung injury, which is one of the leading causes of acute kidney injury-related death.
Mingjun Du, Lei Yang, Jianmin Gu, Jiawei Wu, Yiwen Ma, Tao Wang   +5 more
doaj   +1 more source

Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation

Journal of Innate Immunity, 2021
Previous research has indicated an intimate functional communication between mast cells (MCs) and neutrophils during inflammatory conditions, but the nature of such communication is not fully understood.
Gunnar Pejler, Sultan Alanazi, Mirjana Grujic, Jeremy Adler, Anna-Karin Olsson, Christian P. Sommerhoff, Fabio Rabelo Melo   +6 more
doaj   +1 more source

Ménage-à-trois: The ratio of bicarbonate to CO2 and the pH regulate the capacity of neutrophils to form NETs

Frontiers in Immunology, 2016
In this study we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation.
Christian Maueröder, Aparna Siddharth Mahajan, Susanne Paulus, Stefanie Nowecki, Jonas Hahn, Deborah Kienhöfer, Mona Helena Biermann, Philipp Tripal, Ralf Philipp Friedrich, Luis Enrique Munoz, Markus F Neurath, Christoph Becker, Georg Andreas Schett, Martin Herrmann, Moritz Leppkes   +14 more
doaj   +1 more source

Neutrophil Activation and Neutrophil Extracellular Trap Formation in Dialysis PatientsPlain-Language Summary

Kidney Medicine, 2020
Rationale & Objective: The removal of metabolic waste by passing blood through synthetic tubing and membranes generates an immune response, even with the most biocompatible materials available.
Scott Bieber, Kimberly A. Muczynski, Christian Lood   +2 more
doaj   +1 more source

Neutrophil Extracellular Trap Killing Assay of Candida albicans

Bio-Protocol, 2020
Fungal pathogen Candida albicans is one of the top leading causes of overall healthcare-associated bloodstream infections worldwide. Neutrophil is the major effector cell to clear C. albicans infection.
Sheng-Yang Wu, Betty Wu-Hsieh
doaj   +1 more source