Results 21 to 30 of about 1,212 (168)

Diverse stimuli engage different neutrophil extracellular trap pathways

eLife, 2017
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans ...
Elaine F Kenny, Alf Herzig, Renate Krüger, Aaron Muth, Santanu Mondal, Paul R Thompson, Volker Brinkmann, Horst von Bernuth, Arturo Zychlinsky   +8 more
doaj   +1 more source

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha, Binita Shrestha, Takashi Ito, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama   +8 more
doaj   +1 more source

Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology

Biomolecules, 2019
Neutrophil extracellular traps (NETs), a unique DNA framework decorated with antimicrobial peptides, have been in the scientific limelight for their role in a variety of pathologies ranging from cystic fibrosis to cancer.
Mithunan Ravindran, Meraj A. Khan, Nades Palaniyar   +2 more
doaj   +1 more source

The emerging role of neutrophil extracellular traps in fungal infection

Frontiers in Cellular and Infection Microbiology, 2022
Fungal infections are global public health problems and can lead to substantial human morbidity and mortality. Current antifungal therapy is not satisfactory, especially for invasive, life-threatening fungal infections. Modulating the antifungal capacity
Chuting Liang, Ni Lian, Min Li, Min Li
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Anti-Inflammatory Neutrophil Functions in the Resolution of Inflammation and Tissue Repair

Cells, 2022
Neutrophils are highly abundant circulating leukocytes that are amongst the first cells to be recruited to sites of infection or sterile injury. Their ability to generate and release powerful cytotoxic products ties with their role in host defence from ...
Waywen Loh, Sonja Vermeren
doaj   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Effects of bromelain, melatonin, and thymoquinone on neutrophil extracellular trap formation and macrophage polarization in experimental periodontitis [PDF]

Journal of Applied Oral Science
Periodontitis is a chronic inflammatory disease characterized by dysregulated immune responses leading to alveolar bone loss. Formation of neutrophil extracellular traps and macrophage polarization play critical roles in its pathogenesis, and natural ...
Şükran Acipinar, Mustafa Ozkaraca, Ufuk Okkay, Ali Sefa Mendil   +3 more
doaj   +2 more sources

Neutrophil Activated by the Famous and Potent PMA (Phorbol Myristate Acetate)

Cells, 2022
This review will briefly outline the major signaling pathways in PMA-activated neutrophils. PMA is widely used to understand neutrophil pathways and formation of NETs.
Hylane Luiz Damascena, Wendy Ann Assis Silveira, Mariana S. Castro, Wagner Fontes   +3 more
doaj   +1 more source