Results 11 to 20 of about 1,212 (168)

Periodontal therapy increases neutrophil extracellular trap degradation

Innate Immunity, 2020
In periodontitis, polymorphonuclear leucocytes (PMNs) are activated. They entrap and eliminate pathogens by releasing neutrophil extracellular traps (NETs).
Carolyn GJ Moonen, Kirsten GD Buurma, Mouri RJ Faruque, Maria G Balta, Erol Liefferink, Sergio Bizzarro, Elena A Nicu, Bruno G Loos   +7 more
doaj   +1 more source

The Role of Neutrophil Extracellular Traps in Cancer

Frontiers in Oncology, 2021
Neutrophils are vital components of innate and adaptive immunity. It is widely acknowledged that in various pathological conditions, neutrophils are activated and release condensed DNA strands, triggering the formation of neutrophil extracellular traps ...
Bo-Zong Shao, Yi Yao, Jin-Ping Li, Ning-Li Chai, En-Qiang Linghu   +4 more
doaj   +1 more source

Histone Acetylation Promotes Neutrophil Extracellular Trap Formation

Biomolecules, 2019
Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J. Hamam, Meraj A. Khan, Nades Palaniyar   +2 more
doaj   +1 more source

Molecular mechanisms and therapeutic target of NETosis in diseases

MedComm, 2022
Evidence shows that neutrophils can protect the host against pathogens in multiple ways, including the formation and release of neutrophil extracellular traps (NETs).
Jiayu Huang, Weiqi Hong, Meihua Wan, Limin Zheng   +3 more
doaj   +1 more source

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

Haematologica, 2013
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps.
Marein Schimmel, Erfan Nur, Bart J. Biemond, Gerard J. van Mierlo, Shabnam Solati, Dees P. Brandjes, Hans-Martin Otten, John-John Schnog, Sacha Zeerleder   +8 more
doaj   +1 more source

Chromatin swelling drives neutrophil extracellular trap release

Nature Communications, 2018
Neutrophilic granulocytes release their own DNA (NETosis) as neutrophil extracellular traps to capture pathogens. Here, the authors use time-resolved fluorescence and atomic force microscopy and reveal that NETosis is highly organized into three distinct
Elsa Neubert, Daniel Meyer, Francesco Rocca, Gökhan Günay, Anja Kwaczala-Tessmann, Julia Grandke, Susanne Senger-Sander, Claudia Geisler, Alexander Egner, Michael P. Schön, Luise Erpenbeck, Sebastian Kruss   +11 more
doaj   +1 more source

The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases

Journal of Innate Immunity, 2022
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
doaj   +1 more source

Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia

BMC Cardiovascular Disorders, 2020
Background This study investigated neutrophil activation and neutrophil-derived extracellular traps formation in coronary artery ectasia. Methods We enrolled 90 patients who underwent coronary angiography, and included 30 patients with coronary artery ...
Yuchao Guo, Ruifeng Liu, Lianfeng Chen, Wei Wu, Shuyang Zhang   +4 more
doaj   +1 more source

Neutrophil extracellular trap clearance by synovial macrophages in gout

Arthritis Research & Therapy, 2021
Background Monosodium urate (MSU) crystals, i.e., the central etiological factors in gouty arthritis, induce the formation of neutrophil extracellular traps (NETs).
Ji Hye Jeong, Su Jin Choi, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong   +7 more
doaj   +1 more source

Neutrophil extracellular traps mediate neuro-immunothrombosis

Neural Regeneration Research
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions.
Jianbo Lou, Jianning Zhang, Quanjun Deng, Xin Chen   +3 more
doaj   +1 more source