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Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review
Autoimmunity Reviews, 2017 Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA ...
Keum Hwa Lee +2 more
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Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs)
Comprehensive Physiology, 2021Abstract Uncontrolled immune system activation amplifies end‐organ injury in hypertension. Nonetheless, the exact mechanisms initiating this exacerbated inflammatory response, thereby contributing to further increases in blood pressure (BP), are still being revealed.
Cameron G, McCarthy +5 more
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Neutrophil extracellular traps in dermatology: Caught in the NET
Journal of Dermatological Science, 2016Neutrophil, or polymorphonuclear granulocytes (PMN) constitute the most abundant type of leucocytes in peripheral human blood. One of the major advances in the last decade was the discovery of neutrophil extracellular trap (NET) formation: a process by which neutrophils externalize web-like chromatin strands decorated with antimicrobial peptides. These
Jochen H O, Hoffmann, Alexander H, Enk
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Neutrophil Extracellular Traps (NET) and SARS-CoV-2
Immunopharmacology and Immunotoxicology, 2022NETosis is a type of neutrophil extinction that outcome in the liberation of extracellular chromatin and protein accumulation, which contains antiviral proteins, produced by an external pathogen. Neutrophils can show bipolar action in special circumstances. This event, along with other circumstances, involves COVID-19.
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Macrophage Clearance of Neutrophil Extracellular Traps (NETs)
The Journal of Immunology, 2022Abstract Neutrophil Extracellular Traps (NETs) are formed from dying neutrophils expelling their contents to capture pathogens and limit the spread of infection. While they are beneficial during infection, overproduction of NETs or the inability to degrade them can be pathogenic.
J Paige Gronevelt +2 more
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The net effect of ANCA on neutrophil extracellular trap formation
Kidney International, 2018The formation of neutrophil extracellular traps induced by antineutrophil cytoplasmic autoantibodies has been implicated in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis. Kraaij et al. now provide evidence that excessive neutrophil extracellular trap formation in vitro induced by sera from patients with ...
Heeringa, Peter +2 more
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Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release [PDF]
International Journal of Molecular Sciences, 2017 Neutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release of neutrophil extracellular traps (NETs). Antibiotics have an immunomodulating effect, and they can influence the properties of numerous immune cells, including ...
Weronika Bystrzycká +2 more
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Neutrophil extracellular traps: casting the NET over pathogenesis
Current Opinion in Microbiology, 2007Neutrophil extracellular traps (NETs) are considered to be part of the human innate immunity because they trap and kill pathogens. NETs are formed by activated neutrophils and consist of a DNA backbone with embedded antimicrobial peptides and enzymes. They are involved in host defense during pneumococcal pneumonia, streptococcal necrotizing fasciitis ...
Florian, Wartha +3 more
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The
Abstract Neutrophil extracellular traps ( NET s), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli.
Alexander, Stephan, Mario, Fabri
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Neutrophil extracellular traps (NETs) and fibrotic diseases
International ImmunopharmacologyFibrosis, a common cause and serious outcome of organ failure that can affect any organ, is responsible for up to 45% of all deaths in various clinical settings. Both preclinical models and clinical trials investigating various organ systems have shown that fibrosis is a highly dynamic process. Although many studies have sought to gain understanding of
Xiaojiao Wu, Yang Yang
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