Results 261 to 270 of about 845,167 (291)

Macrophage Clearance of Neutrophil Extracellular Traps (NETs)

The Journal of Immunology, 2022
Abstract Neutrophil Extracellular Traps (NETs) are formed from dying neutrophils expelling their contents to capture pathogens and limit the spread of infection. While they are beneficial during infection, overproduction of NETs or the inability to degrade them can be pathogenic.
J Paige Gronevelt, Michael Pisano, Julie Rumble   +2 more
openaire   +1 more source

The net effect of ANCA on neutrophil extracellular trap formation

Kidney International, 2018
The formation of neutrophil extracellular traps induced by antineutrophil cytoplasmic autoantibodies has been implicated in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis. Kraaij et al. now provide evidence that excessive neutrophil extracellular trap formation in vitro induced by sera from patients with ...
Heeringa, Peter, Rutgers, Abraham, Kallenberg, Cees G M   +2 more
openaire   +3 more sources

Neutrophil extracellular traps: casting the NET over pathogenesis

Current Opinion in Microbiology, 2007
Neutrophil extracellular traps (NETs) are considered to be part of the human innate immunity because they trap and kill pathogens. NETs are formed by activated neutrophils and consist of a DNA backbone with embedded antimicrobial peptides and enzymes. They are involved in host defense during pneumococcal pneumonia, streptococcal necrotizing fasciitis ...
Florian, Wartha, Katharina, Beiter, Staffan, Normark, Birgitta, Henriques-Normark   +3 more
openaire   +2 more sources

Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release [PDF]

International Journal of Molecular Sciences, 2017
Neutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release of neutrophil extracellular traps (NETs). Antibiotics have an immunomodulating effect, and they can influence the properties of numerous immune cells, including ...
Aneta Manda-Handzlik, Aneta Moskalik, Olga Ciepiela   +2 more
exaly   +3 more sources

The NET , the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Experimental Dermatology, 2015
Abstract Neutrophil extracellular traps ( NET s), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli.
Alexander, Stephan, Mario, Fabri
openaire   +2 more sources

Neutrophil extracellular traps (NETs) and fibrotic diseases

International Immunopharmacology
Fibrosis, a common cause and serious outcome of organ failure that can affect any organ, is responsible for up to 45% of all deaths in various clinical settings. Both preclinical models and clinical trials investigating various organ systems have shown that fibrosis is a highly dynamic process. Although many studies have sought to gain understanding of
Xiaojiao Wu, Yang Yang
openaire   +2 more sources

Unweaving the NET: Microbial strategies for neutrophil extracellular trap evasion

Microbial Pathogenesis, 2022
Circa 20 years ago, a new type of defense mechanism was described in neutrophils. At the time, this mechanism corresponded to the extrusion of DNA, associated with histones, granular and cytosolic proteins from the cell and it was produced in response to exposure to pathogens or interleukins.
Luis Janssen, Herick Sampaio Muller, Vicente de Paulo Martins   +2 more
openaire   +2 more sources

Acinetobacter baumannii Escape From Neutrophil Extracellular Traps (NETs)

Journal of Infection and Chemotherapy, 2015
Acinetobacter baumannii and Pseudomonas aeruginosa are the same aerobic gram-negative bacillus and are usually harmless but cause infectious diseases in compromised hosts. Neutrophils play a critical role in infective protection against the extracellular growth of bacteria.
Takane Kikuchi-Ueda, Go Kamoshida, Yasuo Ono   +2 more
exaly   +4 more sources

Detection, Visualization, and Quantification of Neutrophil Extracellular Traps (NETs) and NET Markers

2019
Neutrophil extracellular traps (NETs) have been identified as a key player in the pathogenesis of infection and inflammation in human and animals. On the one hand, NETs have been characterized as fundamental to the innate immune defense against different pathogens since they are able to entrap and immobilize invading pathogens.
Nicole, de Buhr, Maren, von Köckritz-Blickwede   +1 more
openaire   +2 more sources

Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction

Blood Reviews, 2012
The innate immune system orchestrated by leukocytes primarily neutrophils, serves to remove dead and dying host cells and to provide protection against invasion by pathogens. Failure of this system results in the onset of sepsis leading to grave consequences for the host.
Elizabeth E, Gardiner, Robert K, Andrews
openaire   +2 more sources