Results 61 to 70 of about 13,856 (332)

Antimikrobielle Peptide in induziertem Sputum [PDF]

open access: yes, 2006
Die COPD gilt bezüglich Klinik und Epidemiologie als die bedeutendste und gravierendste Langzeitkomplikation eines langjährigen Nikotinabusus. In der vorliegenden Arbeit wurde untersucht, ob diese Entzündung bereits bei jungen, klinisch noch gesunden ...
Bals, Robert (Dr. Dr.)   +1 more
core   +1 more source

Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage

open access: yesFrontiers in Immunology, 2022
Although tremendous effort has been exerted to elucidate the pathogenesis of severe COVID-19 cases, the detailed mechanism of moderate cases, which accounts for 90% of all patients, remains unclear yet, partly limited by lacking the biopsy tissues. Here,
Tiecheng Wang   +29 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]

open access: yes, 2016
α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos   +3 more
core   +3 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Frequency of Antineutrophil Cytoplasmic Antibodies (ANCA) in Some Autoimmune Diseases

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are a heterogeneous group of autoantibodies with a broad spectrum of clinically associated diseases. The diagnostic value is established for Proteinase 3 (PR3)-ANCA as well as Myeloperoxidase (MPO)-ANCA.
Falah S. Manhal, Husam M. Abbas
doaj   +3 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

The vegetation map of France going numerical: a new harmonised national geographical database [PDF]

open access: yes, 2014
5 pagesIn this paper we present the digitalisation of the map of the vegetation of France edited in 64 sheets by the CNRS between 1947 and 1991. The geographical covers and the databases built during this work are gathered in a geographical database ...
Badeau, Vincent   +8 more
core   +2 more sources

Evaluation of stress responses induced by the loading density in dromedary camel (Camelus dromedarius) [PDF]

open access: yes, 2018
The intensity of stress depends on several external factors, such as distance and conditions of transport, climate change, the nature of the journey and the vehicle used, etc.
Belhouari, Abderrahmane   +7 more
core   +1 more source

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