Results 61 to 70 of about 51,568 (202)

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Early‐onset idiopathic pyoderma gangrenosum

JEADV Clinical Practice
Neutrophilic dermatoses are autoinflammatory disorders characterised by sterile cutaneous inflammatory neutrophilic infiltrates. This group of diseases is rare in infants and children, where sepsis is the diagnosis of exclusion.
Deepika Roshith, Christopher Rawlingson, Timothy H. Clayton, Chitra Sethuraman, Peter D. Arkwright   +4 more
doaj   +1 more source

Erosive pustular dermatosis of the lower legs (EPDL): A rarely diagnosed neutrophilic dermatosis of the elderly

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Erosive pustular dermatosis of the lower legs (EPDL) is a rarely diagnosed, chronic inflammatory skin disease that occurs predominantly in elderly people. Predisposing factors include skin atrophy, chronic venous insufficiency, and trauma. Although the pathogenesis of EPDL has not yet been conclusively clarified, there are ongoing discussions ...
Joachim Dissemond, Jan Kottner, Jan‐Malte Placke, Cornelia Erfurt‐Berge   +3 more
wiley   +1 more source

LESIONES CUTÁNEAS ASOCIADAS A FACTORES ESTIMULANTES DE COLONIAS EN UNA PACIENTE CON CÁNCER DE PULMÓN

Revistas Argentina de Medicina, 2017
Se conoce como síndrome de Sweet a una dermatosis neutrofílica que se manifiesta como placas cutáneas sensibles o dolorosas de aparición brusca. El factor estimulante de colonias de granulocitos (G-CSF) es un factor de crecimiento hematopoyético cuya ...
Alexis Ostinelli, Walter Astorino, Marcelo Zylberman   +2 more
doaj   +2 more sources

Primary Cutaneous Neutrophilic Disorders [PDF]

European Medical Journal Dermatology, 2013
The ‘classical neutrophilic dermatoses’ comprise a spectrum of disorders characterised by rash and neutrophilia. The defining histopathological finding is of a sterile neutrophilic infiltrate.
Victoria J. Hogarth, Bláithín Moriarty
doaj  

Diagnostic Agreement in Subepidermal Blistering Diseases: Is ELISA Test Reliable as Direct Immunofluorescence? A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Objectives Direct immunofluorescence (DIF) is the gold standard for diagnosing subepidermal blistering diseases (SBDs). However, DIF requires specialized expertise; therefore, alternative immunological methods such as enzyme‐linked immunosorbent assays (ELISA) are worth exploring. The aim of this review was to evaluate the diagnostic agreement
Romeo Patini, Gioele Gioco, Michele Davide Mignogna, Stefania Leuci, Francesco Scilla, Davide Gentile, Cosimo Rupe, Enrico Russo, Anna Schiavelli, Carlo Lajolo   +9 more
wiley   +1 more source

Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen

Clinical Case Reports, 2017
Key Clinical Message Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat ...
Mostafa F. M. Saleh, Yogen Saunthararajah   +1 more
doaj   +1 more source

A Dermal Plaque on the Arm

JEADV Clinical Practice, EarlyView.
Claudine Howard‐James, Aisling Nolan, Graham Woods, Ian McDonald   +3 more
wiley   +1 more source

TNF Inhibitor Therapy in Corticosteroid‐Resistant or ‐Dependent Pediatric Neutrophilic Dermatosis

Pediatric Dermatology, EarlyView.
ABSTRACT Neutrophilic dermatoses are rare in children. Systemic corticosteroids are the first‐line treatment, but guidelines for second‐line therapies are lacking. We report five cases of children with systemic steroid‐resistant/dependent neutrophilic dermatoses, successfully treated with tumor necrosis factor inhibitors.
Laure Chêne, Thomas Hubiche, Jean‐Marie De Guillebon, Maella Severino‐Freire, Emmanuelle Bourrat, Sébastien Barbarot, Alice Phan, Christine Chiaverini   +7 more
wiley   +1 more source