Results 211 to 220 of about 1,037,717 (382)
Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision
Advanced Healthcare Materials, EarlyView.Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja +6 more
wiley +1 more source
Neutrophil-binding immunoglobulin G in systemic lupus erythematosus. [PDF]
, 1979 Gordon Starkebaum, William P. Arend
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Engineering of a functional protein corona with a synergistic heparin‐ATIII complex significantly improves hemocompatibility of PEG nanoparticles. Through deliberate engineering of the protein corona, a 4‐fold reduction in coagulation activation (F1 + 2) without inducing adverse thromboinflammatory reactions (CD11b, C5a) is achieved without disrupting ...
Vaidehi Londhe +5 more
wiley +1 more source
Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Advanced Healthcare Materials, EarlyView.This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall +14 more
wiley +1 more source
Calcium ion-dependent adenosine triphosphatase activity and plasma-membrane phosphorylation in the human neutrophil [PDF]
, 1979 Claudio Schneider, C Mottola, D Romeo
openalex +1 more source
Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun +9 more
wiley +1 more source
Eosinophils versus Neutrophils in Host Defense [PDF]
, 1979 David Bass, Pamela Szejda
openalex +1 more source
Advanced Materials, EarlyView.This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and antiinflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai +6 more
wiley +1 more source