Results 131 to 140 of about 2,550,357 (246)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

New combinations in Balearic plants

open access: yes, 1997
Three new nomenclatural changes of vascular plants endemic of the Balearic archipelago are proposed: Ranunculus paludosus Poiret subsp. Barceloi (Grau) Rosselló, L. Sáez & N. Torres, Ononis crispa L. subsp. zschackei (F. Herm.) Rosselló & L. Sáez and Ophrys bertolonii Morettii subsp. baleárica (Delforge) Rosselló & L. Sáez.
Rosselló, Josep Antoni   +2 more
openaire   +3 more sources

A new combination of 5'- and 3'-untranslated regions increases the expression of mRNAs in vitro and in vivo. [PDF]

open access: yesVavilovskii Zhurnal Genet Selektsii
Antropov DN   +9 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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