Results 111 to 120 of about 69,557 (255)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A simplified model of Heavy Vector Singlets for the LHC and future colliders
Journal of High Energy PhysicsWe study a simplified model of two colourless heavy vector resonances in the singlet representation of SU(2) L , with zero and unit hypercharge. We discuss mixing with the Standard Model gauge bosons due to electroweak symmetry breaking, semi-analytic ...
Michael J. Baker +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Searching for axial neutral current non-standard interactions of neutrinos by DUNE-like experiments
Journal of High Energy PhysicsThe increasingly precise neutrino experiments raise the hope for searching for new physics through studying the impact of Neutral Current (NC) Non-Standard Interactions (NSI) of neutrinos with matter fields.
S. Abbaslu +3 more
doaj +1 more source
New supersymmetric gauge theories: the double tensor multiplet and its interactions [PDF]
Nuclear Physics B, 2000 openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Searching dark photons using displaced vertices at Belle II — with backgrounds
Journal of High Energy PhysicsDark photons in the MeV to GeV range with kinetic mixing of the order of ≲ 10 −4 − 10 −3 can be produced in significant numbers at low energy colliders such as Belle II. Their decay length can be macroscopic raising the hope for a fairly clean search via
Joerg Jaeckel, Anh Vu Phan
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source