Results 91 to 100 of about 18,947,439 (256)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Lychnos, 2019 Already in the 1960s, internationalisation was seen as a pressing concern for the humanities as Sweden, among other Western European countries, saw an increased interest in research policy in the context of the technological hype of the Cold War ...
Hampus Östh Gustafsson
doaj
Nordic Journal of Arts, Culture and HealthPurpose: To discuss theoretically the ‘biopsychosocial model’ when relating to more existential and spiritually oriented approaches to health and Health Humanities and to display a new non-therapeutic and philosophical dialogue approach to Art & Health ...
Finn Thorbjørn Hansen
doaj +1 more source
Off the Tracks: Laying New Lines for Digital Humanities Scholars [PDF]
, 2011 Since the 1990s, digital humanities centers have sprung up in increasing numbers to accommodate the challenges to the traditional humanities posed by new technologies, as well as the particular forms of knowledge and interdisciplinarity they entail.
Brian Croxall +19 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Digital Publishing in the Arts and Humanities
, 2012 Digital Publishing in the Arts and Humanities in four parts. [Part One:] Digital Publishing in the Arts and Humanities: An Overview (Melanie Schlosser).
Carlson, Wayne +2 more
core +1 more source