Results 111 to 120 of about 126,433 (311)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Digital Humanities in the German-Speaking World
, 2019 The topic of digital humanities provokes widely varying views in the German-speaking world. In Germany digitalization efforts are often limited to a regional scale.
Gänssbauer, Monika,, Monika Gänßbauer
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Visualizing "Big Data" in the Arts and Humanities
, 2012 Visualizing "Big Data" in the Arts and Humanities recorded in four parts. [Part One:] Reading Big Data as a Humanist: The Humanities Visualization Studio (David J. Staley).
Labov, Jessie +2 more
core
The Laboratory Turn: Exploring Discourses, Landscapes, and Models of Humanities Labs
, 2020 The goal of this paper is to track the path of the formation of the laboratory turn in the humanities and understand the conditions, meanings, and functions of humanities labs.
Pawlicka-Deger, Urszula
core
An examination of the physical and the digital qualities of humanities research
, 2008 Traditionally humanities scholars have worked in physical environments and with physical artefacts. Libraries are familiar places, built on cultural traditions over thousands of years, and books are comfortable research companions.
Rimmer, J +9 more
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Artificial Intelligence and the Limits of the Humanities
Er(r)goThe complexity of cultures in the modern world is now beyond human comprehension. Cognitive sciences cast doubts on the traditional explanations based on mental models.
Włodzislaw Duch
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source