Results 111 to 120 of about 929,301 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Boston Univeristy Wind Ensemble [PDF]
, 2000 This is the concert program of the Boston University Wind Ensemble performance on Thursday, February 17, 2000 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue. Works performed were Suite Francaise, Op.
School of Music, Boston University
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Boston University Wind Ensemble [PDF]
, 2004 This is the concert program of the Boston University Wind Ensemble performance on Thursday, October 21, 2004 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue.
School of Music, Boston University
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Learning from Jesus’ Wife: What Does Forgery Have to Do with the Digital Humanities? [PDF]
, 2019 McGrath’s chapter on the so-called Gospel of Jesus’ Wife sets aside as settled the question of the papyrus’ authenticity, and explores instead what we can learn about the Digital Humanities and scholarly interaction in a digital era from the way the ...
McGrath, James F
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Artificial Intelligence and the Limits of the Humanities
Er(r)goThe complexity of cultures in the modern world is now beyond human comprehension. Cognitive sciences cast doubts on the traditional explanations based on mental models.
Włodzislaw Duch
doaj +1 more source
, 2010 Coming Up Taller is a report filled with hope, a narrative about youth learning to paint, sing, write plays and poems, take photographs, make videos and play drums or violins.
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