Results 121 to 130 of about 126,433 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

GraphEidos: A Dataset of Visual Rhetoric in Digital Humanities

Journal of Open Humanities Data
This data article introduces GraphEidos, a new open-access dataset that documents how visuals have been used and discussed in digital humanities (DH) journal publications. The dataset covers various forms of visual representations, their captions, and in-
Rongqian Ma, Kai Li, Ranvir Singh Virk
doaj   +1 more source

Off the Tracks: Laying New Lines for Digital Humanities Scholars [White Paper]

, 2011
The emergence of digital humanities centers over the last twenty years has generated a new set of career possibilities for scholars working within the field.
Maryland Institute for Technology in the Humanities, Clement, Tanya, Reside, Doug   +2 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

New Cohort of McGillicuddy Humanities Center Fellows Begin Research

, 2021
Four University of Maine students have joined the McGillicuddy Humanities Center (MHC) this semester as research fellows: Delaney Burns, Elizabeth Dalton, Grace Royle, and Haley Santerre.
Clement and Linda McGillicuddy Humanities Center
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Reflecting on psychology through a double lens: The Psychological Humanities as an integrated approach

Rivista Internazionale di Filosofia e Psicologia
In this paper, we argue that the recent debates andproclaimed crises in psychology are partly due to a reflection deficit and the reductionist understanding of psychology as exclusively a science.
Lisa Malich, David Keller
doaj   +1 more source

Shared Horizons: Data, BioMedicine, and the Digital Humanities (Final Performance Report)

, 2013
The Maryland Institute for Technology in the Humanities (MITH), working in cooperation with the Office of Digital Humanities of the National Endowment for the Humanities, the National Library of Medicine of the National Institutes for Health, and the ...
Maryland Institute for Technology in the Humanities, Fraistat, Neil   +1 more
core