Results 101 to 110 of about 126,433 (311)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Humanistyka: pracownia, centrum czy laboratorium?

open access: yesTeksty Drugie, 2017
The fact that laboratories are becoming increasingly popular in the humanities forces us to think about the field’s structural transformation – its sources, meaning and consequences.
Urszula Pawlicka
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Existential Health and Spiritual Recovery: Two Possible New and Important Concepts in the Health Humanities

open access: yesNordic Journal of Arts, Culture and Health
Purpose: To discuss theoretically the ‘biopsychosocial model’ when relating to more existential and spiritually oriented approaches to health and Health Humanities and to display a new non-therapeutic and philosophical dialogue approach to Art & Health ...
Finn Thorbjørn Hansen
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Planlös forskning?

open access: yesLychnos, 2019
Already in the 1960s, internationalisation was seen as a pressing concern for the humanities as Sweden, among other Western European countries, saw an increased interest in research policy in the context of the technological hype of the Cold War ...
Hampus Östh Gustafsson
doaj  

The ends of critique: methods, institutions, politics New critical humanities./ edited by Kathrin Thiele, Birgit M. Kaiser, and Timothy O'Leary.

open access: yes, 2021
Includes bibliographical references and index."The Ends of Critique re-examines the stakes of critique in the 21st century. In view of increasingly complex socio-political realities and shifts in a fully globalized world, the roles and manners of ...
Thiele Kathrin   +2 more
core  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

The Humanities as Contradiction: Against the New Enclosures

open access: yesHumanities, 2018
This essay begins by surveying our current moment in the humanities, diagnosing the language of crisis that frames much of the discourse about them. It argues that the crisis is a manufactured economic one not a symbolic one.
Christopher Breu
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

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