Results 91 to 100 of about 1,363,811 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Standard Model couplings and collider signatures of a light scalar

, 2008
The electroweak symmetry breaking (EWSB) sector of the Standard Model can be far richer and more interesting than the usual single scalar doublet model. We explore scenarios where the EWSB sector is nearly scale invariant and consequently gives rise to a
A. Ali, Andreas Ross, C. Kao, JiJi Fan, Walter D. Goldberger, Witold Skiba   +5 more
core   +1 more source

Portal Connecting Dark Photons and Axions [PDF]

, 2017
The dark photon and the axion (or axion-like particle) are popular light particles of the hidden sector. Each of them has been actively searched for through the couplings called the vector portal and the axion portal. We introduce a new portal connecting
Kaneta, Kunio, Lee, Hye-Sung, Yun, Seokhoon   +2 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Searching for a new light gauge boson with axial couplings in muon beam dump experiments

Journal of High Energy Physics
We present a formalism for new U(1) interactions involving weak hypercharge, baryon, and lepton numbers, and a possible axial symmetry generator F A in the presence of a second Brout-Englert-Higgs doublet.
Pierre Fayet, María Olalla Olea-Romacho
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

New Light Particle Searches with PADME

Acta Physica Polonica B Proceedings Supplement
The PADME experiment at Laboratori Nationali di Frascati is designed to study possible dark matter explanations relying on the presence of a light particle that acts as a mediator between the visible and the hidden sectors. Three data-taking runs have resulted in the collection of more than \(10^{13}\) positrons-on-target.
openaire   +1 more source

An effective up quark mass from new light particles

Physics Letters B, 1991
Abstract I consider a model where an effective current mass for the up quark is provided by the interactions of a new neutral light colored scalar and a charge 1 3 colorless fermion. The model has no strong CP problem. A new confining U (1) prevents the occurence of physical states with fractional charges.
openaire   +1 more source

Black hole superradiance as a probe of ultra-light new particles [PDF]

Proceedings of the International Astronomical Union, 2016
AbstractBosonic fields around a spinning black hole can be amplified via ‘superradiance’, a wave analogue of the Penrose process, which extracts energy and momentum from the black hole. For hypothetical ultra-light bosons, with Compton wavelengths on ≳ km scales, such a process can lead to the exponential growth of gravitationally bound states around ...
openaire   +1 more source