Results 71 to 80 of about 382,262 (315)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Monte Carlo modeling of polarized light propagation in biological tissues. [PDF]

, 2004
The application of polarization-sensitive optical coherence tomography (PS-OCT) creates new possibilities for biomedical imaging. In this work, we present a numerical simulation of the signal from a PS-OCT interferometer. We explore the possibility to
Meglinski, I. V., Gangnus, S. V., Matcher, S. J.   +2 more
core  

Inhaled steroid/tobacco smoke particle interactions: a new light on steroid resistance [PDF]

Respiratory Research, 2009
Inhaled steroid resistance is an obstacle to asthma control in asthmatic smokers. The reasons of this phenomenon are not yet entirely understood. Interaction of drug particles with environmental tobacco smoke (ETS) could change the aerodynamic profile of the drug through the particle coagulation phenomenon.
Nicolini Gabriele, Mazza Roberto, De Marco Cinzia, Ruprecht Ario, Invernizzi Giovanni, Boffi Roberto   +5 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy.

, 2009
OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.
Prasad, A, McConnell, JP, Ford, MA, Lavi, S, Sandhu, GS, Rihal, CS, Lerman, LO, Lerman, A, Hartman, SJ   +8 more
core   +1 more source

ALPINIST: Axion-Like Particles In Numerous Interactions Simulated and Tabulated

Journal of High Energy Physics, 2022
Proton beam dump experiments are among the most promising strategies to search for light and feebly interacting states such as axion-like particles (ALPs). The interpretation of these experiments is however complicated by the wide range of ALP models and
Jan Jerhot, Babette Döbrich, Fatih Ertas, Felix Kahlhoefer, Tommaso Spadaro   +4 more
doaj   +1 more source

ENGINEERING IMAGING: USING PARTICLE IMAGE VELOCIMETRY TO SEE PHYSIOLOGY IN A NEW LIGHT [PDF]

Clinical and Experimental Pharmacology and Physiology, 2009
SUMMARY Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution.
Andreas, Fouras, Jonathan, Dusting, John, Sheridan, Masaaki, Kawahashi, Hiroyuki, Hirahara, Kerry, Hourigan   +5 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Inhibiting the Thermal Gelation of Copolymer Stabilized Nonaqueous Dispersions and the Synthesis of Full Color PMMA Particles [PDF]

, 2016
Polymeric particle dispersions have numerous potential applications; currently one of the most relevant is their use as inks in electrophoretic displays.
Simon J. Holder (1866523), Kate E. Belsey (2553823), Topping, Claire, Belsey, Kate E., Claire Topping (2553826), Louise D. Farrand (2553820), Holder, Simon J., Farrand, Louise D.   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source