Results 81 to 90 of about 382,262 (315)

Searching for a new light gauge boson with axial couplings in muon beam dump experiments

open access: yesJournal of High Energy Physics
We present a formalism for new U(1) interactions involving weak hypercharge, baryon, and lepton numbers, and a possible axial symmetry generator F A in the presence of a second Brout-Englert-Higgs doublet.
Pierre Fayet, María Olalla Olea-Romacho
doaj   +1 more source

New light weakly-coupled particle searches in a neutrino detector

open access: yesJournal of Physics: Conference Series, 2014
Neutrino detectors at the accelerator machines of the Intensity Frontier in particle physics are becoming commonplace. As their capabilities are being understood, they seem to have the potential for studies beyond the neutrino oscillations measurements.
A Hatzikoutelis   +3 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Full correction of scattering effects by using the radiative transfer theory for improved quantitative analysis of absorbing species in suspensions [PDF]

open access: yes, 2013
Sample-to-sample photon path length variations that arise due to multiple scattering can be removed by decoupling absorption and scattering effects by using the radiative transfer theory, with a suitable set of measurements.
Thennadil, Suresh N.   +1 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Optical sorting and manipulation of microscopic particles

open access: yes, 2007
Over the last few decades, the use of light to control and manipulate microscopic particles has become widespread. These methods are enabling new areas of research to flourish across the physical and biological sciences.
Milne, Graham
core  

Astrophysical flux of dark particles as a solution to the KM3NeT and IceCube tension over KM3-230213A

open access: yesJournal of High Energy Physics
We entertain the possibility that transient astrophysical sources can produce a flux of dark particles that induce ultra-high-energy signatures at neutrino telescopes such as IceCube and KM3NeT.
Yasaman Farzan, Matheus Hostert
doaj   +1 more source

Black hole superradiance as a probe of ultra-light new particles [PDF]

open access: yesProceedings of the International Astronomical Union, 2016
AbstractBosonic fields around a spinning black hole can be amplified via ‘superradiance’, a wave analogue of the Penrose process, which extracts energy and momentum from the black hole. For hypothetical ultra-light bosons, with Compton wavelengths on ≳ km scales, such a process can lead to the exponential growth of gravitationally bound states around ...
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Simulation of superresolution holography for optical tweezers [PDF]

open access: yes, 2008
Optical tweezers manipulate microscopic particles using foci of light beams. Their performance is therefore limited by diffraction. Using computer simulations of a model system, we investigate the application of superresolution holography for two ...
Thomson, L.C.   +14 more
core   +1 more source

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