Results 61 to 70 of about 367,039 (268)

ALPINIST: Axion-Like Particles In Numerous Interactions Simulated and Tabulated

Journal of High Energy Physics, 2022
Proton beam dump experiments are among the most promising strategies to search for light and feebly interacting states such as axion-like particles (ALPs). The interpretation of these experiments is however complicated by the wide range of ALP models and
Jan Jerhot, Babette Döbrich, Fatih Ertas, Felix Kahlhoefer, Tommaso Spadaro   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ENGINEERING IMAGING: USING PARTICLE IMAGE VELOCIMETRY TO SEE PHYSIOLOGY IN A NEW LIGHT [PDF]

Clinical and Experimental Pharmacology and Physiology, 2009
SUMMARY Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution.
Andreas, Fouras, Jonathan, Dusting, John, Sheridan, Masaaki, Kawahashi, Hiroyuki, Hirahara, Kerry, Hourigan   +5 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Searching for a new light gauge boson with axial couplings in muon beam dump experiments

Journal of High Energy Physics
We present a formalism for new U(1) interactions involving weak hypercharge, baryon, and lepton numbers, and a possible axial symmetry generator F A in the presence of a second Brout-Englert-Higgs doublet.
Pierre Fayet, María Olalla Olea-Romacho
doaj   +1 more source

New light weakly-coupled particle searches in a neutrino detector

Journal of Physics: Conference Series, 2014
Neutrino detectors at the accelerator machines of the Intensity Frontier in particle physics are becoming commonplace. As their capabilities are being understood, they seem to have the potential for studies beyond the neutrino oscillations measurements.
A Hatzikoutelis, S Kotelnikov, B A Bambah, S P Kasetti   +3 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Astrophysical flux of dark particles as a solution to the KM3NeT and IceCube tension over KM3-230213A

Journal of High Energy Physics
We entertain the possibility that transient astrophysical sources can produce a flux of dark particles that induce ultra-high-energy signatures at neutrino telescopes such as IceCube and KM3NeT.
Yasaman Farzan, Matheus Hostert
doaj   +1 more source