Results 51 to 60 of about 367,039 (268)

Keeping it simple: simplified frameworks for long-lived particles at neutrino facilities

Journal of High Energy Physics, 2023
Modern-day accelerator neutrino facilities are excellent venues for searches for new-physics particles. Many distinct new-physics models predict overlapping signatures and phenomenology in these experiments.
Brian Batell, Wenjie Huang, Kevin J. Kelly   +2 more
doaj   +1 more source

Nucleon Decays into Light New Particles in Neutrino Detectors

Physical Review Letters
Proton and neutron decays into light new particles X can drastically change the experimental signatures and benefit from the complementarity of large water-Cherenkov neutrino detectors such as Super- and Hyper-Kamiokande and tracking detectors such ...
Julian Heeck, Ian M. Shoemaker
openaire   +4 more sources

Relativistic free-particle quantization on the light-front: New aspects [PDF]

AIP Conference Proceedings, 2004
We use the light-front machinery to study the behavior of a relativistic free particle and obtain the quantum commutation relations from the classical Poisson brackets. We argue that the usual projection onto the light-front coordinates for these from the covariant commutation ralations does not reproduce the expected results.
Sales, J. H. O., Suzuki, A. T., Zambrano, G. E. R.   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Quark-universal U(1) breaking scalar at the LHC

Journal of High Energy Physics
If the quarks or leptons are charged under a new U(1) gauge symmetry, then besides a Z′ boson there must exist at least one new boson whose decay products include Standard Model particles. In the case of a minimal symmetry breaking sector, that new boson
Lorin Armbruster, Bogdan A. Dobrescu, Felix Yu   +2 more
doaj   +1 more source

LEX-EFT: the Light Exotics Effective Field Theory

Journal of High Energy Physics, 2023
We propose the creation of a Light Exotics Effective Field Theory (LEX-EFT) catalog. LEX-EFT is a generic framework to capture all interactions between the Standard Model (SM) and all (or at least a large class of) theoretically allowed exotic states ...
Linda M. Carpenter, Taylor Murphy, Matthew J. Smylie   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Inhaled steroid/tobacco smoke particle interactions: a new light on steroid resistance [PDF]

Respiratory Research, 2009
Inhaled steroid resistance is an obstacle to asthma control in asthmatic smokers. The reasons of this phenomenon are not yet entirely understood. Interaction of drug particles with environmental tobacco smoke (ETS) could change the aerodynamic profile of the drug through the particle coagulation phenomenon.
Nicolini Gabriele, Mazza Roberto, De Marco Cinzia, Ruprecht Ario, Invernizzi Giovanni, Boffi Roberto   +5 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source