Results 111 to 120 of about 1,362,749 (337)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Explanation of the hints for a 95 GeV Higgs boson within a 2-Higgs Doublet Model

Journal of High Energy Physics
We suggest an explanation for and explore the consequences of the excess around 95 GeV in the di-photon and di-tau invariant mass distributions recently reported by the CMS collaboration at the Large Hadron Collider (LHC), together with the discrepancy ...
A. Belyaev, R. Benbrik, M. Boukidi, M. Chakraborti, S. Moretti, S. Semlali   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A facility to Search for Hidden Particles (SHiP) at the CERN SPS [PDF]

, 2015
A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the
Alaoui, M. A. El, Anelli, M., Aoki, S., Arduini, G., Back, J. J., Bagulya, A., Baldini, W., Baranov, A., Barker, G. J., Barsuk, S., Battistin, M., Bauche, J., Bay, A., Bayliss, V., Bellagamba, L., Bencivenni, G., Bertani, M., Bezshyyko, O., Bick, D., Bingefors, N., Blondel, A., Bogomilov, M., Bonacorsi, D., Bondarenko, D., Bonivento, W., Borburgh, J., Boyarsky, A., Bradshaw, T., Brenner, R., Breton, D., Brook, N., Bruschi, M., Buonaura, A., Buontempo, S., Cadeddu, S., Calcaterra, A., Calviani, M., Campanelli, M., Capoccia, C., Cecchetti, A., Chatterjee, A., Chauveau, J., Chepurnov, A., Chernyavskiy, M., Ciambrone, P., Cicalo, C., Conti, G., Cornelis, K., Courthold, M., D'Ambrosio, N., Dallavalle, M. G., De Lellis, G., De Serio, M., Dedenko, L., Di Crescenzo, A., Di Marco, N., Dib, C., Dietrich, J., Dijkstra, H., Domenici, D., Donskov, S., Druzhkin, D., Ebert, J., Egede, U., Egorov, A., Egorychev, V., Enik, T., Etenko, A., Fabbri, F., Fabbri, L., Fedorova, G., Felici, G., Ferro-Luzzi, M., Fini, R. A., Franke, M., Fraser, M., Galati, G., Giacobbe, B., Goddard, B., Golinka-Bezshyyko, L., Golubkov, D., Golutvin, A., Gorbunov, D., Graverini, E., Grenard, J-L, Guler, A. M., Hagner, C., Hakobyan, H., Helo, J. C., Horvath, D., Iacovacci, M., Iaselli, G., Jacobsson, R., Kadenko, I., Kamiscioglu, C., Kamiscioglu, M., Khaustov, G., Khotjansev, A., Kilminster, B., Kim, V., Kitagawa, N., Kodama, K., Kolesnikov, A., Kolev, D., Komatsu, M., Konovalova, N., Koretskiy, S., Korolko, I., Korzenev, A., Kovalenko, S., Kudenko, Y., Kuznetsova, E., Lacker, H., Lai, A., Lanfranchi, G., Lauria, A., Lebbolo, H., Levy, J. -M., Lista, L., Loverre, P., Lukiashin, A., Lyubovitskij, V. E., Malinin, A., Manfredi, M., Marrone, A., Matev, R., Mermod, P., Messomo, E. N., Mikado, S., Mikhaylov, Yu., Miller, J., Milstead, D., Mineev, O., Mingazheva, R., Mitselmakher, G., Miyanishi, M., Monacelli, P., Montanari, A., Montesi, M. C., Morello, G., Morishima, K., Movtchan, S., Murzin, V., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nurakhov, N., Obinyakov, B., Ocalan, K., Ogawa, S., Oreshkin, V., Orlov, A., Osborne, J., Pacholek, P., Panman, J., Paoloni, A., Paparella, L., Pastore, A., Patel, M., Perillo-Marcone, A., Petridis, K., Petrushin, M., Poli-Lener, M., Polukhina, N., Polyakov, V., Prokudin, M., Puddu, G., Pupilli, F., Rademakers, F., Rakai, A., Rawlings, T., Redi, F., Ricciardi, S., Rinaldesi, R., Roganova, T., Rogozhnikov, A., Rokujo, H., Romaniouk, A., Rosa, G., Rostovtseva, I., Rovelli, T., Ruchayskiy, O., Ruf, T., Saitta, G., Samoylenko, V., Samsonov, V., Saputi, A., Sato, O., Schmidt-Parzefall, W., Serra, N., Sgobba, S., Shaposhnikov, M., Shatalov, P., Shaykhiev, A., Shchutska, L., Shevchenko, V., Shibuya, H., SHiP Collaboration, Shitov, Y., Silverstein, S., Simone, S., Skorokhvatov, M., Smirnov, S., Solodko, E., Sosnovtsev, V., Spighi, R., Spinetti, M., Starkov, N., Storaci, B., Strabel, C., Strolin, P., Takahashi, S., Teterin, P., Tioukov, V., Tommasini, D., Treille, D., Tsenov, R., Tshchedrina, T., Ull, A. Sanz, Ustyuzhanin, A., van Herwijnen, E., Vankova-Kirilova, G., Vannucci, F., Venturi, V., Villa, M., Vincke, Heinz, Vincke, Helmut, Vladymyrov, M., Xella, S., Yalvac, M., Yershov, N., Yilmaz, D., Yilmazer, A. U., Zaitsev, Y., Zoccoli, A.   +235 more
core   +1 more source

Investigation of magneto-optical properties of ferrofluids by laser light scattering techniques

, 2017
Investigation of magnetooptical characteristics of ferrofluids is an important task aimed at the development of novel optoelectronic systems. This article reports on the results obtained in the experimental studies of the factors that affect the ...
Kuzmin, Yu I, Nepomnyashchaya, E K, Pleshakov, I V, Prokofiev, A V, Velichko, E N   +4 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Limits on an exotic Higgs decay from a recast ATLAS four-lepton analysis

Journal of High Energy Physics
The ATLAS collaboration, using 139 fb−1 of 13 TeV collisions from the Large Hadron Collider, has placed limits on the decay of a Z boson to three dark photons.
Junyi Cheng, Rabia Husain, Lingfeng Li, Matthew J. Strassler   +3 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Magnetically amplified tunneling of the 3rd kind as a probe of minicharged particles

, 2012
We show that magnetic fields significantly enhance a new tunneling mechanism in quantum-field theories with photons coupling to fermionic minicharged particles. We propose a dedicated laboratory experiment of the light-shining-through-walls type that can
Döbrich, Babette, Gies, Holger, Karbstein, Felix, Neitz, Norman   +3 more
core   +1 more source

Hopfield Neural Networks for Online Constrained Parameter Estimation With Time‐Varying Dynamics and Disturbances

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley   +1 more source