Results 51 to 60 of about 349,351 (306)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Probing light neutralinos from pair-produced sleptons with displaced vertices at the high-luminosity LHC

open access: yesJournal of High Energy Physics
We study light neutralinos χ ~ 1 0 $$ \left({\overset{\sim }{\chi}}_1^0\right) $$ with masses ranging from 10 GeV to several hundred GeV within the framework of R-parity-violating (RPV) supersymmetry.
Giovanna Cottin   +4 more
doaj   +1 more source

LEX-EFT: the Light Exotics Effective Field Theory

open access: yesJournal of High Energy Physics, 2023
We propose the creation of a Light Exotics Effective Field Theory (LEX-EFT) catalog. LEX-EFT is a generic framework to capture all interactions between the Standard Model (SM) and all (or at least a large class of) theoretically allowed exotic states ...
Linda M. Carpenter   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Searching for string bosenovas with gravitational wave detectors

open access: yesJournal of High Energy Physics
We study the phenomenology of a string bosenova explosion in vector superradiance clouds around spinning black holes, focusing on the observable consequences in gravitational wave detectors and accelerometers.
Dawid Brzeminski   +3 more
doaj   +1 more source

Search for new light particles at ILC main beam dump

open access: yes, 2020
7 pages, 5 figures.
Sakaki, Yasuhito, Ueda, Daiki
openaire   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Baryonic dark forces in electron-beam fixed-target experiments

open access: yesJournal of High Energy Physics
New GeV-scale dark forces coupling predominantly to quarks offer novel signatures that can be produced directly and searched for at high-luminosity colliders. We compute the photon-proton and electron-proton cross sections for producing a GeV-scale gauge
Safa Ben Othman   +2 more
doaj   +1 more source

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