Results 61 to 70 of about 349,351 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Constraints on photon mass and dark photon from the Jovian magnetic field

Journal of High Energy Physics
The Jovian magnetic field, being the strongest and largest planetary one in the solar system, could offer us new insights into possible microscopic scale new physics, such as a non-zero mass of the Standard Model (SM) photon or a light dark photon ...
Shi Yan, Lingfeng Li, JiJi Fan
doaj   +1 more source

ALPINIST: Axion-Like Particles In Numerous Interactions Simulated and Tabulated

Journal of High Energy Physics, 2022
Proton beam dump experiments are among the most promising strategies to search for light and feebly interacting states such as axion-like particles (ALPs). The interpretation of these experiments is however complicated by the wide range of ALP models and
Jan Jerhot, Babette Döbrich, Fatih Ertas, Felix Kahlhoefer, Tommaso Spadaro   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effect of the Synthesis Conditions on the Morphology, Luminescence and Scintillation Properties of a New Light Scintillation Material Li2CaSiO4:Eu2+ for Neutron and Charged Particle Detection [PDF]

, 2022
I. Komendo, V. Mechinsky, A. Fedorov, G. Dosovitskiy, Victor Schukin, Daria Kuznetsova, M. P. Zykova, Yury Velikodny, M. Korjik   +8 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

ENGINEERING IMAGING: USING PARTICLE IMAGE VELOCIMETRY TO SEE PHYSIOLOGY IN A NEW LIGHT [PDF]

Clinical and Experimental Pharmacology and Physiology, 2009
SUMMARY Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution.
Andreas, Fouras, Jonathan, Dusting, John, Sheridan, Masaaki, Kawahashi, Hiroyuki, Hirahara, Kerry, Hourigan   +5 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Search for a new heavy scalar particle decaying into a Higgs boson and a new scalar singlet in final states with one or two light leptons and a pair of $τ$-leptons with the ATLAS detector [PDF]

, 2023
G. Aad, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, L. Adámek, S. V. Addepalli, Matt Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, Melike Akbiyik, T. P. A. Åkesson, Андрей Акимов, D. Akiyama, Nilima Nilesh Akolkar, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, M. Aleksa, Igor Alexandrov, C. Alexa, T. Alexopoulos, Fabrizio Alfonsi, M. Algren, M. Alhroob, B. Ali, Hanadi Ali, S. Ali, Samuel William Alibocus, B. M. M. Allbrooke, G. Alimonti, W. Alkakhi, C. Allaire, Benedict Allbrooke, Julia Frances Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, Mario Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, Christoph Amelung, M. Amerl, C. G. Ames, D. Amidei, Susana Patricia Amor dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, Stylianos Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella   +99 more
openalex   +1 more source

Probing new light particles in tritium beta decay with the KATRIN experiment

Lauer, Joscha
openalex   +3 more sources