Results 71 to 80 of about 22,033,058 (288)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
New Zealand Nurses’ Reports on Hospital Care: An International Comparison
, 2007 Despite the differences in health care systems, nursing shortages and their contributing factors and consequences no longer seem to be solely country-specific.
Mary Finlayson +2 more
core
Nurses contribution to the resolution of ethical dilemmas in context [PDF]
Background: New nursing roles and advances in care and treatments have resulted in nurses facing increasingly complex ethical dilemmas in practice; nurses are therefore required to engage effectively in ethical decision-making.
Barlow, Nichola
core +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Study on status quo and correlation of social anxiety and resilience level of new nurses
Huli yanjiu, 2016 Objective:To probe into the social anxiety and resilience level of new nurses and the correlation between them,and provide basis for the development of targeted interventions.Methods:A total of 672 new nurses from 2014 to 2015 received the questionnaire ...
叶赟, 倪静玉, 万静波, 谭敏娟
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Surveying Primary Health Care Nurses
, 2006 A summary of the research project "Managing Diabetes Patients by Primary Health Care Nurses" was outlined and published as a letter primarily to inform the Primary Health Care Nurses in Auckland of this ...
Daly, BM
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source