Results 81 to 90 of about 22,033,058 (288)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Jurnal Ilmiah Kesehatan, 2019 Background: Competency issues and the lack of implementation of an orientation program with the preceptorship method are problems and require solutions / solutions.
yuliartiningsih yuliartiningsih +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Public Health Nurses in New Zealand: The Impact of Invisibility [PDF]
, 2001 Public health nurses have provided care to individuals, families and communities in New Zealand since the early 1920s. This research study examined the role of the public health nurse.
Karen McBride, Jill Clendon
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Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Irish Nurses Organisation annual report 1999.
, 2000 It is my great pleasure, as President of the Irish Nurses Organisation, to present this Annual Report for the year 1999. It is a report which records a substantial amount of work on behalf of nurses, midwives and their professions. The shadow of a
Irish Nurses Organisation (INO)
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
New Standards of Practice for Australian Mental Health Nurses
, 2009 The purpose of this study was to review and redevelop the 'Standards of Practice for Mental Health Nurses in Australia' published by the Australian and New Zealand College of Mental Health Nurses in 1995.
Eley, Diann +5 more
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Nurses' knowledge of delirium: A survey of theoretical knowing [PDF]
, 2016 The aim of this exploratory study was to assess whether nurses from a regional base hospital had sufficient theoretical knowledge to assess and manage delirium in the clinical setting. Delirium is a well-recognised, preventable condition commonly seen in
Christensen, Martin +1 more
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