Results 71 to 80 of about 5,290,284 (268)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
A FRAMEWORK FOR SUCCESSFUL NEW PRODUCT DEVELOPMENT
South African Journal of Industrial Engineering, 2019 To exploit the competitive advantage of a core competency, such as new technology development, an organisation must be capable of developing that technology efficiently and effectively.
Pienaar, Cornelia +2 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
New Product Development in Virtual Environment [PDF]
Purpose - The literature on the topic has evolved exponentially since eight years ago. Relaying on a review of studies published in recent years, this article proposes and discusses a framework which incorporates a set of virtual teams involved in a new ...
Ahmed, Shamsuddin +2 more
core +1 more source
New product development in an emerging economy: analysing the role of supplier involvement practices by using Bayesian Markov chain Monte Carlo technique [PDF]
, 2014 The research question is whether the positive relationship found between supplier involvement practices and new product development performances in developed economies also holds in emerging economies.
Dekkers, R., Kanapathy, K., Khong, K.W.
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Eyes on new product development. [PDF]
J Ocul Pharmacol Ther, 2015 Novack GD.
europepmc +5 more sources
Frontiers in PharmacologyIntroduction: In causal inference, the correct formulation of the scientific question of interest is a crucial step. The purpose of this study was to apply causal inference principles to external control analysis using observational data and illustrate ...
Letizia Polito +7 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Ownership structure and new product development in transnational corporations in China [PDF]
, 2008 This paper examines the relationship between the ownership structure and new product development (NPD) at the affiliates of transnational corporations in China.
Li, Xiaoying, Liu, Xiaming, Thomas, H.
core