Results 71 to 80 of about 636,620 (264)

Improving the Relationship Between the Neuromodulation Industry and Academia: Commentary and Strategy

Journal of Pain Research
Michael E Schatman,1,2 Daniel A Adams,1 Sayed Emal Wahezi3 1Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY, USA; 2Department of Population Health – Division of Medical Ethics, NYU ...
Schatman ME, Adams DA, Wahezi SE
doaj  

Promoting Inclusion, Diversity, and Equity in Pain Science

Journal of Pain Research, 2023
Tonya M Palermo,1 Karen Deborah Davis,2 Didier Bouhassira,3 Robert W Hurley,4 Joel D Katz,5 Francis J Keefe,6 Michael E Schatman,7,8 Dennis C Turk,1 David Yarnitsky9 1Department of Anesthesiology & Pain Medicine, University of Washington, Seattle ...
Palermo TM, Davis KD, Bouhassira D, Hurley RW, Katz JD, Keefe FJ, Schatman ME, Turk DC, Yarnitsky D   +8 more
doaj  

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Advanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan, Wengui Shi, Long Qin, Yuman Dong, Huinian Zhou, Zeyuan Yu, Xiangyan Jiang, Zuoyi Jiao   +16 more
wiley   +1 more source

Telehealth is Crucial for Pain Medicine: Patients and Doctors are at the Brink, and Medicare Must Act Now

Journal of Pain Research
Scott G Pritzlaff,1 Naileshni Singh,1 Chinar Sanghvi,1 Michael E Schatman2,3 1Department of Anesthesiology and Pain Medicine, University of California, Davis, Sacramento, CA, USA; 2Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU ...
Pritzlaff SG, Singh N, Sanghvi C, Schatman ME   +3 more
doaj  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

The Need for Urgent Action and Reform: Is the Veterans Administration’s Pain Care Under Fire?

Journal of Pain Research
Krishnan Chakravarthy,1– 3 Michael E Schatman4,5 1Department of Anesthesiology and Pain Medicine, VA San Diego Healthcare, San Diego, CA, USA; 2Innovative Pain Treatment Solutions and Surgery Center, Temecula, CA, USA; 3Solaris Research Institute ...
Chakravarthy K, Schatman ME
doaj  

History education in Ethiopian secondary schools (1943–1991): Why it could not yield the desired results? A historical analysis

Cogent Education
History teaching in secondary school is intended to be a source of knowledge, hastening the nation-building process and enhancing the critical thinking and analytical skills of youth.
Ageru Shume Nadew, Fantahun Ayele Ibrahim, Aychgrew Hadera Hailu   +2 more
doaj   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source