Results 141 to 150 of about 4,345 (211)
Allergy, EarlyView.This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake +8 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky +28 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Phyllodes tumours of the breast exhibit a spectrum of biologic behaviour, with a predisposition to recur locally and metastasize distantly in their malignant form. There are limited data regarding the optimal surgical approach. Objectives Our systematic review and meta‐analysis aimed to determine the impact of breast conserving ...
Christopher G. Harris +6 more
wiley +1 more source
Two Decades of Multimodal Management of Colorectal Liver Metastases With Long‐Term Outcomes
ANZ Journal of Surgery, EarlyView.ABSTRACT Background The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long‐term survival following liver resection are contested.
Ali Mohtashami +9 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background A shift in the age profile of major trauma patients creates new challenges to trauma system design. Examining historical trends of major trauma in older people allows us to better plan for an effective trauma system. This study explores the clinical characteristics of older adult trauma cases presenting to a level one trauma center ...
Liya Ma +3 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Rural residents are more likely to suffer moderate and severe traumatic brain injury (TBI) and experience delay to definitive care than urban patients. Prior studies comparing these populations were based on hospitalised patients only. We examined TBI outcomes incorporating pre‐hospital mortality to determine the association between
Gareth Rutter +4 more
wiley +1 more source
A Novel Blood‐Based Screening Test for Colorectal Cancer Using Raman Spectroscopy
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Label‐free vibrational spectroscopic techniques (Raman spectroscopy) combined with machine learning (ML) methodologies have huge potential for the development of screening and diagnostic tests in oncology. Traditionally, screening for colorectal cancer (CRC) has relied on immunochemical faecal occult blood (iFOBT) testing; however ...
Jett Karolewski +5 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Paediatric neuromuscular and syndromic scoliosis patients have multiple medical comorbidities that increase the risk of postoperative complications. There is a lack of consistent literature assessing the specific risk factors for complications following scoliosis correction surgery in this high‐risk cohort.
Mai Pham +4 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen +2 more
wiley +1 more source