Results 111 to 120 of about 29,480 (254)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
All Aboard! A re-enactment approach to Victorian Railway Guard’s Clothing
EXARC JournalThis paper examines the form, function and practicality of the clothing worn by late nineteenth century railway guards in Britain. It does so by taking a re-enactment approach, involving the commissioning, wearing, and reporting of replica garments in an
Anthony Dawson
doaj
This Time for Africa: African Conference on Experimental Archaeology (ACE) 2018
EXARC Journal, 2017 Good news: The first African Conference on Experimental Archaeology (ACE) will be held in Johannesburg on the 20th to the 22nd of March 2018. Join us for presentations, posters, mini-workshops, demonstrations and round-table discussions of experiments in
Silje Evjenth Bentsen
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of the American College of Cardiology, 2021 Tomohiro Fujisaki +4 more
openaire +2 more sources
EXARC Journal, 2017 Between the 1st to the 12th of June 2017, a huge festival called "Times and Epochs" (Времена и эпохи - Cобрание) was organized in Moscow. This was the occassion to gather participants not only from Russia, but also from many other countries, and ...
Milica Tapavički-Ilić, Artūrs Tomsons
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Clinical and economic studies of eptifibatide in coronary stenting
Therapeutics and Clinical Risk Management, 2014 Tilak Pasala, Prasongchai Sattayaprasert, Pradeep K Bhat, Ganesh Athappan, Sanjay Gandhi The Heart and Vascular Center, Case Western Reserve University/MetroHealth, Cleveland, OH, USA Abstract: Platelet adhesion and aggregation at the site of coronary ...
Pasala T +4 more
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source