Results 91 to 100 of about 29,480 (254)
Hunting with Cane: Traditional Cherokee Blowguns and Darts
EXARC Journal, 2013 The Cherokee Indians were a large Southeastern tribe who occupied land in North Carolina, South Carolina, Georgia, Alabama, Tennessee and Virginia. During the Historic Period, the Cherokee were one of the Five Civilized Tribes and even had their own ...
Doug Meyer
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
EXARC Journal, 2017 The book consists of the rewritten essay of a master thesis. The author got his master's degree as a battlefield and conflict archaeologist from the Centre of Battlefield Archaeology at University of Glasgow founded by Professor Dr. Tony Pollard in 2006.
Thit Birk Petersen
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The Itinerant Artist: Portraiting Early America Using Scissors, Soot and Beer
EXARC JournalHundreds of thousands of profile portraits known as silhouettes were created in the new United States in the first decade of 1800 alone. Since the 1990s, museum conservators have wondered how to best care for the materials of these objects in their ...
Lauren Muney
doaj
Colonial Williamsburg: Archaeology, Interpretation and Phenomenology
EXARC Journal, 2019 This paper stems from a keynote talk I was invited to give at the Archaeology for the People: Exhibition, Experience and Performance conference, in Kernave, Lithuania, in September of 2018.
Peter Inker
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Interview: Richard Rees, a professional furrier with over 30 years of experience
EXARC JournalWe are talking to Richard Rees, a professional furrier with over 30 years of experience in the profession. He has undertaken an unprecedented project—creating the fifth Qingailisaq parka. The parka is famous for being so difficult to make.
J. Kateřina Dvořáková
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source