Results 101 to 110 of about 29,480 (254)

Re-Creating an Aboriginal Earth Oven with Clayey Heating Elements: Experimental Archaeology and Paleodietary Implications

open access: yesEXARC Journal, 2018
Earth ovens may relate to different ancestral cooking techniques, serving specific needs and functions. In eastern and south-eastern Australia, they were a significant element of a thriving pre-colonial Aboriginal culture.
Maurizio Campanelli   +4 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

A Personal Experience in Communicating History: Tales From the River Trent

open access: yesEXARC Journal, 2013
Saturday 1 September dawns gloriously, and is unseasonably sunny. Our fingers are crossed that this is the Indian Summer we'd been praying for all August since we intend to do a lot of walking in the next three weeks.
Sophia Collins
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Conference Review: Reconstructive and Experimental Archaeology Conference REARC 2013

open access: yesEXARC Journal, 2014
The 4th Annual Reconstructive and Experimental Archaeology Conference was recently held in Gastonia, NC at the Schiele Museum of Natural History. The conference theme was Education and Reconstructive and Experimental Archaeology.
David Wescott
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Book Review: The Value of an Archaeological Open-Air Museum is in its Use by Roeland Paardekooper

open access: yesEXARC Journal, 2014
Question: What has 40,000 legs, likes to tell stories and pops up all over Europe? Answer: An archaeological open-air museum. OK, not the most brilliant riddle in the world, but the point is that with publication of Dr Paardekooper’s monograph we now ...
Ronan O’Flaherty
doaj  

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