Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
EXARC Journal, 2018 Earth ovens may relate to different ancestral cooking techniques, serving specific needs and functions. In eastern and south-eastern Australia, they were a significant element of a thriving pre-colonial Aboriginal culture.
Maurizio Campanelli +4 more
doaj
Does cognition matter? Current pedagogical practice and the need for reform [PDF]
, 2016 Recent debate in the educational sphere highlights the continuing dilemma that is the creation and implementation of a true 21st century classroom in secondary schools across Australia.
Coleman, Clara +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Personal Experience in Communicating History: Tales From the River Trent
EXARC Journal, 2013 Saturday 1 September dawns gloriously, and is unseasonably sunny. Our fingers are crossed that this is the Indian Summer we'd been praying for all August since we intend to do a lot of walking in the next three weeks.
Sophia Collins
doaj
User Education in Academic Libraries: A Century in Retrospect [PDF]
, 1980 published or submitted for ...
Tucker, John Mark
core
Gene-Environment Interaction in the Era of Precision Medicine -- Fix the Potholes or Start Building a New Road? [PDF]
, 2020 Álvarez-Castro Jm
openalex
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Book Review: The Value of an Archaeological Open-Air Museum is in its Use by Roeland Paardekooper
EXARC Journal, 2014 Question: What has 40,000 legs, likes to tell stories and pops up all over Europe? Answer: An archaeological open-air museum. OK, not the most brilliant riddle in the world, but the point is that with publication of Dr Paardekooper’s monograph we now ...
Ronan O’Flaherty
doaj
Protestant Ecumenism and Theology in China Since Edinburgh 1910 [PDF]
, 2014 Bays DH +11 more
core +1 more source