Results 161 to 170 of about 298,387 (354)

All Aboard! A re-enactment approach to Victorian Railway Guard’s Clothing

open access: yesEXARC Journal
This paper examines the form, function and practicality of the clothing worn by late nineteenth century railway guards in Britain. It does so by taking a re-enactment approach, involving the commissioning, wearing, and reporting of replica garments in an
Anthony Dawson
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

EXARC visits Moscow

open access: yesEXARC Journal, 2017
Between the 1st to the 12th of June 2017, a huge festival called "Times and Epochs" (Времена и эпохи - Cобрание) was organized in Moscow. This was the occassion to gather participants not only from Russia, but also from many other countries, and ...
Milica Tapavički-Ilić, Artūrs Tomsons
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Bifurcation PCI Technique in the Era of Newer-Generation Drug-Eluting Stents: Insights from a Systematic Review and Meta-Analysis of Randomized Trials

open access: yesJournal of the American College of Cardiology, 2021
Tomohiro Fujisaki   +4 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Book Review: Crafting in the World, Materiality in the Making by Burke and Spencer-Wood

open access: yesEXARC Journal, 2019
Archaeologists dream of books with comprehensive coverage that address specific gaps in knowledge and at the same time address theoretical issues and newer concerns about the nature of craft in a direct method.
Linda Anderson
doaj  

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