Results 171 to 180 of about 298,387 (354)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Conference Review: OpenArch/IMTAL Sweden 2012

open access: yesEXARC Journal, 2013
As a long-standing member of IMTAL (International Museums Theatre Alliance – www.imtal-europe.org) I have always enjoyed their conferences. The workshops and participatory events are held in fantastic venues with theatrics to entertain and inform ...
Lynne Ashton
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Clinical and economic studies of eptifibatide in coronary stenting

open access: yesTherapeutics and Clinical Risk Management, 2014
Tilak Pasala, Prasongchai Sattayaprasert, Pradeep K Bhat, Ganesh Athappan, Sanjay Gandhi The Heart and Vascular Center, Case Western Reserve University/MetroHealth, Cleveland, OH, USA Abstract: Platelet adhesion and aggregation at the site of coronary ...
Pasala T   +4 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Book Review: Experimentelle Archäologie in Europa, Bilanz 2011

open access: yesEXARC Journal, 2013
Bilanz 2011 once again supplies an exciting, diverse and interesting view into the world of experimental archaeology. Published by EXAR in cooperation with the Pfahlbaumuseum Unteruhldingen, Isensee Verlag, Oldenburg 2011, 270 pp, ISBN 978-3-89995-794 ...
Sina Lorbeer-Klausnitz
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Book Review: "Experiments Past" Edited by Jodi Reeves Flores and Roeland P. Paardekooper

open access: yesEXARC Journal, 2014
The publication in 1979 of the John Coles’ book Experimental Archaeology can be called the vademecum of the experimental archaeology. Many particular experiments have been published since then, such as A Bibliography of Replicative Experiments in ...
Clara Masriera i Esquerra
doaj  

Naval Engineering and Labor Specialization during the Industrial Revolution [PDF]

open access: yes
This paper explores the roles of capital- and technology-skill complementarities in labor allocation decisions within the U.S. Navy. During the latter 19th century the ocer corps was highly specialized, and was split between groups of line and sta ocers.
Ahmed S. Rahman, Darrell J. Glaser
core  

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