Results 151 to 160 of about 298,387 (354)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

This Time for Africa: African Conference on Experimental Archaeology (ACE) 2018

EXARC Journal, 2017
Good news: The first African Conference on Experimental Archaeology (ACE) will be held in Johannesburg on the 20th to the 22nd of March 2018. Join us for presentations, posters, mini-workshops, demonstrations and round-table discussions of experiments in
Silje Evjenth Bentsen
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Conference Review: Reconstructive and Experimental Archaeology Conference REARC 2013

EXARC Journal, 2014
The 4th Annual Reconstructive and Experimental Archaeology Conference was recently held in Gastonia, NC at the Schiele Museum of Natural History. The conference theme was Education and Reconstructive and Experimental Archaeology.
David Wescott
doaj  

Unanswered questions over NHS health checks [PDF]

, 2010
Davies, M., Khunti, K., Sattar, N., Walker, N.   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Angiotensinogen: a new era beyond lactate as a biomarker? [PDF]

Yanfei Shen, Xinyuan Ding
openalex   +1 more source

Appendix for "Toward a New Era of Rapid Development: Assessing GPT-4-Vision's Capabilities in UML-Based Code Generation

, 2023
Anonymous Anonymous
openalex   +1 more source

Study on the Dilemma and Countermeasures of Vocational Education to Rural Revitalization Strategy in the New Era [PDF]

, 2023
Houmao Zhuang, Jiaying Wang, Yanlei Mi
openalex   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source