Results 41 to 50 of about 29,480 (254)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Recreating Historic European Spindle Spinning

EXARC Journal, 2021
Spinning is a vital step in the production of textiles, whereby fibres are drawn out (drafted) and twisted together to make thread. In the present day, several culturally unique types of spinning are recognised, such as the thigh-rolling technique of ...
Mary Ann Megan Cleaton, Alice Rose Evans, Jane Hunt, Cathelina di Alessandri   +3 more
doaj  

A Comprehensive Review on Digital Detox: A Newer Health and Wellness Trend in the Current Era

Cureus
This research investigates the effects of an electronic detox treatment on the utilization of social media and smartphones, addiction levels, and the general health of individuals. Remarkably, individuals discovered that the digital detox was less challenging than anticipated, with a significant number expressing sensations of pleasure and alleviation.
Anandpara, Gaurang, Kharadi, Ashish, Vidja, Prakash, Chauhan, Yashkumar, Mahajan, Swati, Patel, Jitendra   +5 more
openaire   +2 more sources

Prevention and Early Treatment of Invasive Fungal Infection in Patients with Cancer and Neutropenia and in Stem Cell Transplant Recipients in the Era of Newer Broad-Spectrum Antifungal Agents and Diagnostic Adjuncts [PDF]

Clinical Infectious Diseases, 2007
Invasive fungal infection (IFI) is a leading cause of infection-related mortality among patients with cancer and prolonged neutropenia and among allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease. Invasive candidiasis was the principal IFI in the period predating fluconazole prophylaxis, whereas today, invasive ...
Brahm H, Segal, Nikolaos G, Almyroudis, Minoo, Battiwalla, Raoul, Herbrecht, John R, Perfect, Thomas J, Walsh, John R, Wingard   +6 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Historical Techniques: Cold Gilding

EXARC Journal, 2012
An historal technique of goldplating, described in 18th century literature, was reproduced. This cold-plating technique uses salts of gold, produced by dissolving gold in aqua regia. these salts are then rubbed onto a silver surfaces.
Michiel Langeveld
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Human Gall-Bladder Communicating with Skin: Rare Anatomical Swerve [PDF]

Journal of Clinical and Diagnostic Research, 2013
Cholecysto-cutaneous fistula is an extremely rare phenomenon in present era. We report a case of this rare entity wherein patient presented with unique history of passage of stones per umbilicus.
Arashdeep Singh, Sandeep Bansal
doaj   +1 more source